ArticleNature medicine2020
Visualization of AMPA receptors in living human brain with positron emission tomography.
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Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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54citing papers in PubMed, 1 pooled it
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives.Frontiers in neurology · 2022Pooled it
- AMPA receptor, neuroimaging, and chronic pain.Journal of anesthesia · 2026Review
- Age and sex-dependent alteration in AMPA receptor density in living human brain.European journal of nuclear medicine and molecular imaging · 2026Article
- Performance Evaluation of SmartBrain: A Wearable PET System for Human Brain Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.Molecular psychiatry · 2026Article
- The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression.Molecular psychiatry · 2026Article
- The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics.Psychiatry and clinical neurosciences · 2026Review
- The science of psychedelic medicine.Nature medicine · 2026Review
- Dosimetry and kinetic modelling of [European journal of nuclear medicine and molecular imaging · 2025Article
- Review
- First-in-Human Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients.Molecular psychiatry · 2025Article
- Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography.Molecular psychiatry · 2025Article
- Ketamine and Hydroxynorketamine as Novel Pharmacotherapies for the Treatment of Opioid Use Disorders.Biological psychiatry · 2025Review
- α4β2The Journal of physiology · 2025Article
- The Current State and Future Outlook of PET Tracers for AMPA Receptors.Neuroscience bulletin · 2025Article
- Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025Review
- Systemic increase of AMPA receptors associated with cognitive impairment of long COVID.Brain communications · 2025Article
- Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution.Frontiers in neural circuits · 2025Article
- PET imaging of synaptic vesicle glycoprotein 2 subtype A for neurological recovery in ischemic stroke.European journal of nuclear medicine and molecular imaging · 2024Article
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Authors and funding
37 authors at 8 institutions in 1 country.
Tomoyuki MiyazakiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Waki NakajimaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Mai HatanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yusuke ShibataDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yoko KurokiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Tetsu ArisawaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Asami SerizawaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Akane SanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Sayaka KogamiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Tomomi YamanoueDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Kimito KimuraDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yushi HirataDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yuuki TakadaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yoshinobu IshiwataDepartment of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masaki SonodaDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID http://orcid.org/0000-0002-4612-5728
Masaki TokunagaDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Chie SekiDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Yuji NagaiDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.ORCID http://orcid.org/0000-0001-7005-0749
Takafumi MinamimotoDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.ORCID http://orcid.org/0000-0003-4305-0174
Kazunori KawamuraDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Ming-Rong ZhangDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Naoki IkegayaDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Masaki IwasakiDepartment of Neurosurgery, National Center Hospital of Neurology and Psychiatry, Kodaira, Japan.ORCID http://orcid.org/0000-0002-4204-7144
Naoto KuniiDepartment of Neurosurgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Yuichi KimuraFaculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Japan.ORCID http://orcid.org/0000-0003-4865-6474
Fumio YamashitaDivision of Ultrahigh-Field-Strength MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.
Masataka TaguriDepartment of Data Science, Yokohama City University School of Data Science, Yokohama, Japan.
Hideaki TaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Nobuhiro NagaiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Teruki KoizumiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Michisuke YuzakiDepartment of Physiology, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5750-3544
Hiroki KatoDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Makoto HiguchiDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0628-7036
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. takahast@yokohama-cu.ac.jp.ORCID http://orcid.org/0000-0001-6523-0622
Yokohama City University · JPKeio University · JPNational Institutes for Quantum Science and Technology · JPIwate Medical University · JPKindai University · JPNational Center of Neurology and Psychiatry · JPThe University of Osaka · JPThe University of Tokyo · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA receptors in the living human brain. Here we developed a positron emission tomography (PET) tracer for AMPA receptors. A derivative of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide radiolabeled with
Indexed as
AdultAnimalsBrainCarbon RadioisotopesChromatography, LiquidFemaleHealthy VolunteersHumansMalePhenoxyacetatesPositron-Emission TomographyProtein BindingRatsRats, Sprague-DawleyReceptors, AMPATandem Mass Spectrometry4-(2-(phenylsulfonylamino)ethylthio)-2,6-difluorophenoxyacetamideCarbon-11Carbon RadioisotopesPhenoxyacetatesReceptors, AMPA
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