Evidence map›Paper›PMID 31959985›Full record

ArticleNature2020

The single-cell pathology landscape of breast cancer.

Hartland W Jackson, Jana R Fischer, Vito R T Zanotelli, H Raza Ali, Robert Mechera, Savas D Soysal, Holger Moch, Simone Muenst, Zsuzsanna Varga, Walter P Weber and 1 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 523 papers.

0numbers the graph read from it
0cells of the map it votes in
523citing papers in PubMed
51.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

523 citing papers in PubMed, 939 citations in OpenAlex.

  1. Trial
  2. Targetable S100-RAGE Signaling Mediates Intrinsic Trastuzumab Deruxtecan Resistance in Metastatic Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Emerging technologies in the spatial proteomics landscape.Analytical and bioanalytical chemistry · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Spatium: A Protein Language Foundation Model for Spatial Proteomics.bioRxiv : the preprint server for biology · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

463 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Hartland W Jackson *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Jana R Fischer *Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Vito R T ZanotelliDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
H Raza AliDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.
Robert MecheraDepartment of Surgery, University of Basel and University Hospital Basel, Basel, Switzerland.
Savas D SoysalDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Holger MochInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Simone MuenstInstitute of Pathology and Genetics, University Hospital Basel, Basel, Switzerland.
Zsuzsanna VargaInstitute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
Walter P WeberDepartment of Surgery, University of Basel and University Hospital Basel, Basel, Switzerland.
Bernd BodenmillerDepartment of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland. bernd.bodenmiller@uzh.ch.
University of Zurich · CHUniversity Hospital of Basel · CHUniversity Hospital of Zurich · CHUniversity of Basel · CHETH Zurich · CHLife Science Zurich · CH

Funding

Cancer Research UK 21143Cancer Research UK 25815
6 · The paper itself

Abstract

Single-cell analyses have revealed extensive heterogeneity between and within human tumours

Indexed as

Molecular ImagingSingle-Cell AnalysisBiomarkers, TumorBreast NeoplasmsHumansKaplan-Meier EstimatePhenotypeProportional Hazards ModelsSurvival RateTumor MicroenvironmentBiomarkers, Tumor

Identifiers

PMID31959985
OpenAlexW2999681746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.