ArticleNature neuroscience2020
Whitening of odor representations by the wiring diagram of the olfactory bulb.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 89 citations in OpenAlex.
- Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.eLife · 2026Article
- Synchronization of behavioral and cardiac dynamics in larval zebrafish.Cell reports · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.eLife · 2025Article
- Predicting modular functions and neural coding of behavior from a synaptic wiring diagram.Nature neuroscience · 2024Article
- Wiring of a low-dimensional integrator network.Nature neuroscience · 2024Article
- Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex.Nature communications · 2024Article
- Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon.Current biology : CB · 2024Article
- Studying zebrafish nervous system structure and function in health and disease with electron microscopy.Development, growth & differentiation · 2023Review
- Article
- Functional odor map heterogeneity is based on multifaceted glomerular connectivity in larvaliScience · 2023Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Normative and mechanistic model of an adaptive circuit for efficient encoding and feature extraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cyclic structure with cellular precision in a vertebrate sensorimotor neural circuit.Current biology : CB · 2023Article
- SynapseCLR: Uncovering features of synapses in primary visual cortex through contrastive representation learning.Patterns (New York, N.Y.) · 2023Article
- Artificial homeostatic temperature regulation via bio-inspired feedback mechanisms.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Neuronal computations underlying higher brain functions depend on synaptic interactions among specific neurons. A mechanistic understanding of such computations requires wiring diagrams of neuronal networks. In this study, we examined how the olfactory bulb (OB) performs 'whitening', a fundamental computation that decorrelates activity patterns and supports their classification by memory networks. We measured odor-evoked activity in the OB of a zebrafish larva and subsequently reconstructed the complete wiring diagram by volumetric electron microscopy. The resulting functional connectome revealed an over-representation of multisynaptic connectivity motifs that mediate reciprocal inhibition between neurons with similar tuning. This connectivity suppressed redundant responses and was necessary and sufficient to reproduce whitening in simulations. Whitening of odor representations is therefore mediated by higher-order structure in the wiring diagram that is adapted to natural input patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.