ArticleNature communications2020
Time-of-flight resolved light field fluctuations reveal deep human tissue physiology.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight.Neurophotonics · 2026Article
- Highly parallel, 1060 nm interferometric diffusing wave spectroscopy with a time-of-flight filter.Biomedical optics express · 2026Article
- Rapid Quantitative Imaging of Heterogeneous Tissue Hemoglobin Dynamics Using Spatial Frequency Domain Imaging.Journal of vascular research · 2026Article
- Depth-sensitive assessment of cerebral blood flow and low-frequency oscillations after traumatic brain injury in mice using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Comparison of diffuse correlation spectroscopy analytical models for cerebral blood flow measurements.Journal of biomedical optics · 2025Article
- Fiber-Based Ultra-High-Speed Diffuse Speckle Contrast Analysis System for Deep Blood Flow Sensing Using a Large SPAD Camera.Biosensors · 2025Article
- 1060 nm interferometric near-infrared spectroscopy.Optics letters · 2025Article
- Study of Time-Resolved Dynamics in Turbid Medium Using a Single-Cavity Dual-Comb Laser.ACS photonics · 2024Article
- Tutorial on methods for estimation of optical absorption and scattering properties of tissue.Journal of biomedical optics · 2024Article
- Interferometric near-infrared spectroscopy (iNIRS) reveals that blood flow index depends on wavelength.Biomedical optics express · 2024Article
- Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver.Neurophotonics · 2024Article
- Diffuse Correlation Spectroscopy: A Review of Recent Advances in Parallelisation and Depth Discrimination Techniques.Sensors (Basel, Switzerland) · 2023Review
- Decoding diffuse light scattering dynamics in layered tissues: path length versus fluctuation time scale.Optics letters · 2023Article
- Recovering fetal signals transabdominally through interferometric near-infrared spectroscopy (iNIRS).Biomedical optics express · 2023Article
- Experimental demonstration of a new near-infrared spectroscopy technique based on optical dual-comb: DC-NIRS.Scientific reports · 2023Article
- Non-invasive diffuse optical monitoring of cerebral physiology in an adult swine-model of impact traumatic brain injury.Biomedical optics express · 2023Article
- Agreement in cerebrovascular reactivity assessed with diffuse correlation spectroscopy across experimental paradigms improves with short separation regression.Neurophotonics · 2023Article
- Optimizing a two-layer method for hybrid diffuse correlation spectroscopy and frequency-domain diffuse optical spectroscopy cerebral measurements in adults.Neurophotonics · 2023Article
- Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter.Optica · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Red blood cells (RBCs) transport oxygen to tissues and remove carbon dioxide. Diffuse optical flowmetry (DOF) assesses deep tissue RBC dynamics by measuring coherent fluctuations of multiply scattered near-infrared light intensity. While classical DOF measurements empirically correlate with blood flow, they remain far-removed from light scattering physics and difficult to interpret in layered media. To advance DOF measurements closer to the physics, here we introduce an interferometric technique, surmounting challenges of bulk motion to apply it in awake humans. We reveal two measurement dimensions: optical phase, and time-of-flight (TOF), the latter with 22 picosecond resolution. With this multidimensional data, we directly confirm the unordered, or Brownian, nature of optically probed RBC dynamics typically assumed in classical DOF. We illustrate how incorrect absorption assumptions, anisotropic RBC scattering, and layered tissues may confound classical DOF. By comparison, our direct method enables accurate and comprehensive assessment of blood flow dynamics in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.