ReviewMolecular psychiatry2020
The importance of a developmental perspective in Psychiatry: what do recent genetic-epidemiological findings show?
Review in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Autism-Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System.International journal of environmental research and public health · 2022Pooled it
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- Co-developmental trajectories of emotional symptoms and peer problems from childhood to adolescence: associations with positive and negative mental health outcomes.European child & adolescent psychiatry · 2026Article
- Analysis of gut microbiota and intestinal mucosal neurotransmitter changes and their correlation in adolescent depression mice.Annals of general psychiatry · 2026Article
- Using a Developmental Approach to Investigate Behavioral, Neurodevelopmental, and Depressive Irritability Types.JAACAP open · 2026Article
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- Incorporating farm animal models for the study of neuropsychiatric diseases: Expansion of the possibilities.Cognitive, affective & behavioral neuroscience · 2026Review
- Age- and sex-dependent effects of stressors on activity of the nucleus reuniens of the thalamus.Schizophrenia research · 2025Article
- Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia.Nature communications · 2025Article
- Peripheral MicroRNA Signatures in Adolescent Depression.Biological psychiatry global open science · 2025Article
- Long-lasting Depressive Behavior of Adolescent Chronically Stressed Mice is Mediated by Gut Microbiota Dysbiosis.Molecular neurobiology · 2025Article
- Associations between air pollution and surrounding greenness with internalizing and externalizing behaviors among schoolchildren.Child and adolescent mental health · 2025Article
- Alterations in fecal microbiota composition and cytokine expression profiles in adolescents with depression: a case-control study.Scientific reports · 2025Article
- Perceived indoor annoyances at home and risk of incident depression: A Danish register-based cohort study, 2000-2018.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Long-term physical health conditions and youth anxiety and depression: Is there a causal link?Psychological medicine · 2025Article
- Beyond symptoms: a multi-perspective study on youth with severe and enduring mental health problems.Frontiers in psychiatry · 2025Article
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
- Associations between polygenic risk scores for cardiometabolic phenotypes and adolescent depression and body dissatisfaction.Pediatric research · 2024Article
- Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders.Psychological medicine · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
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Abstract
There is growing appreciation that a developmental perspective is helpful in Psychiatry. However, clinical practice and research, especially in an era of very large sample sizes, often ignore the developmental context. In this perspective piece, we discuss why a developmental view is important in Psychiatry and how recent genetic-epidemiological findings further highlight this. DSM-5 childhood neurodevelopmental disorders such as ADHD, typically onset in early childhood but can persist into adult life; the same ADHD genetic loading appears to contribute across the life course. However, recent longitudinal studies have observed that ADHD symptoms may emerge later during adolescence and adult life in some individuals although the etiology of this late-onset group is unclear. The epidemiology and genetics of depression do not appear to be the same in childhood, adolescence, and adult life. Recent genetic findings further highlight this. Autistic type problems and irritability also appear to show developmental variation in their genetic etiology. These findings raise the question of whether social communication and irritability have the same meaning at different ages. Schizophrenia typically onsets after adolescence. However, it is commonly preceded by childhood antecedents that do not resemble schizophrenia itself but do appear to index schizophrenia genetic liability. We conclude that there is a need for clinicians and scientists to adopt a developmental perspective in clinical practice and research by considering age-at-onset and changes over time as well as different developmental periods when interpreting clinical symptoms.
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