ArticleScientific reports2020
SLA-1 Genetic Diversity in Pigs: Extensive Analysis of Copy Number Variation, Heterozygosity, Expression, and Breed Specificity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
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- NGSMHC: a simple bioinformatics tool for comprehensively typing major histocompatibility complex genes in non-human species using next-generation sequencing data.Animal bioscience · 2026Article
- Baseline Characterization of Swine Leukocyte Antigen Diversity in GFP-Expressing Domestic Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Evaluating the Immunogenic Potential of ApxI and ApxII fromVeterinary sciences · 2025Article
- Multi-tool copy number detection highlights common body size-associated variants in miniature pig breeds from different geographical regions.BMC genomics · 2025Article
- Influence of MHC on genetic diversity and testicular expression of linked olfactory receptor genes.BMC genomics · 2025Article
- Article
- Individual and population diversity of 20 representative olfactory receptor genes in pigs.Scientific reports · 2023Article
- Mooring Stone-Like ArgJournal of virology · 2022Article
- Development of an Immortalized Porcine Fibroblast Cell Panel With Different Swine Leukocyte Antigen Genotypes.Frontiers in genetics · 2022Article
- Comparative Analysis ofVeterinary sciences · 2021Article
- Identification of Promiscuous African Swine Fever Virus T-Cell Determinants Using a Multiple Technical Approach.Vaccines · 2021Article
- Diversity of the Swine Leukocyte Antigen Class I and II in Commercial Pig Populations.Frontiers in veterinary science · 2021Article
- Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain "Estonia 2014".Pathogens (Basel, Switzerland) · 2020Article
- Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus.PloS one · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Swine leukocyte antigens play indispensable roles in immune responses by recognizing a large number of foreign antigens and thus, their genetic diversity plays a critical role in their functions. In this study, we developed a new high-resolution typing method for pig SLA-1 and successfully typed 307 individuals from diverse genetic backgrounds including 11 pure breeds, 1 cross bred, and 12 cell lines. We identified a total of 52 alleles including 18 novel alleles and 9 SLA-1 duplication haplotypes, including 4 new haplotypes. We observed significant differences in the distribution of SLA-1 alleles among the different pig breeds, including the breed specific alleles. SLA-1 duplication was observed in 33% of the chromosomes and was especially high in the biomedical model breeds such as SNU (100%) and NIH (76%) miniature pigs. Our analysis showed that SLA-1 duplication is associated with the increased level of SLA-1 mRNA expression in porcine cells compared to that of the single copy haplotype. Therefore, we provide here the results of the most extensive genetic analysis on pig SLA-1.
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