ArticleNature communications2020
Non-equilibrium signal integration in hydrogels.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dual-Stimuli Responsive Poly(N-acryloyl glycine) Microgels: Investigation of Network Structures and Application for Loading and Release of Biologics.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Mechanically Active Contractile Hydrogels for Skin Wound Repair.Gels (Basel, Switzerland) · 2026Review
- Hydrogel-based neural engineering for skin wound healing.Frontiers in cell and developmental biology · 2026Review
- Unlocking Micro-Origami Energy Storage.ACS applied energy materials · 2024Review
- Light-steerable locomotion using zero-elastic-energy modes.Nature materials · 2024Article
- Transcriptional regulation of living materials via extracellular electron transfer.Nature chemical biology · 2024Article
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Diffusive kinks turn kirigami into machines.Nature communications · 2024Article
- Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Computing Arithmetic Functions Using Immobilised Enzymatic Reaction Networks.Angewandte Chemie (International ed. in English) · 2023Article
- Perpetuating enzymatically induced spatiotemporal pH and catalytic heterogeneity of a hydrogel by nanoparticles.Chemical science · 2022Article
- Transient Host-Guest Complexation To Control Catalytic Activity.Journal of the American Chemical Society · 2022Article
- Progressive Local Accumulation of Self-Assembled Nanoreactors in a Hydrogel Matrix through Repetitive Injections of ATP.Journal of the American Chemical Society · 2022Article
- Using Dissipative Particle Dynamics to Model Effects of Chemical Reactions Occurring within Hydrogels.Nanomaterials (Basel, Switzerland) · 2021Article
- Reaction-diffusion hydrogels from urease enzyme particles for patterned coatings.Communications chemistry · 2021Article
- On the use of catalysis to bias reaction pathways in out-of-equilibrium systems.Chemical science · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Materials that perform complex chemical signal processing are ubiquitous in living systems. Their synthetic analogs would transform developments in biomedicine, catalysis, and many other areas. By drawing inspiration from biological signaling dynamics, we show how simple hydrogels have a previously untapped capacity for non-equilibrium chemical signal processing and integration. Using a common polyacrylic acid hydrogel, with divalent cations and acid as representative stimuli, we demonstrate the emergence of non-monotonic osmosis-driven spikes and waves of expansion/contraction, as well as traveling color waves. These distinct responses emerge from different combinations of rates and sequences of arriving stimuli. A non-equilibrium continuum theory we developed quantitatively captures the non-monotonic osmosis-driven deformation waves and determines the onset of their emergence in terms of the input parameters. These results suggest that simple hydrogels, already built into numerous systems, have a much larger sensing space than currently employed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.