Evidence map›Paper›PMID 31959748›Full record

ArticleNature communications2020

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice.

Yun Rose Li, Kyle D Halliwill, Cassandra J Adams, Vivek Iyer, Laura Riva, Rashid Mamunur, Kuang-Yu Jen, Reyno Del Rosario, Erik Fredlund, Gillian Hirst and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Computational modeling of human genetic variants in mice.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Biochemical analysis of HDNA repair · 2024
    Article
  15. Review
  16. High-LET charged particles: radiobiology and application for new approaches in radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Review
  17. Article
  18. The Contribution of Oxidative Stress toAntioxidants (Basel, Switzerland) · 2023
    Review
  19. Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Yun Rose Li *UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.
Kyle D Halliwill *UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.
Cassandra J Adams *UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.
Vivek IyerExperimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK.
Laura RivaExperimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK.
Rashid MamunurExperimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK.
Kuang-Yu JenUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.
Reyno Del RosarioUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.
Erik FredlundUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.
Gillian HirstUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID http://orcid.org/0000-0002-4502-0035
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0003-3596-4515
David AdamsExperimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK. da1@sanger.ac.uk.ORCID http://orcid.org/0000-0001-9490-0306
Allan BalmainUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94158, USA. allan.balmain@ucsf.edu.ORCID http://orcid.org/0000-0001-6549-7861
University of California, San Francisco · USWellcome Sanger Institute · GBUniversity of California San Diego · US

Funding

Identification of epithelial tumor susceptiility genesU01CA084244 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALMAIN, ALLAN · 1999 to 2013
$13.3M
Systems genetics analysis of tumor evolution in the mouseR35CA210018 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALLAN BALMAIN · 2017 to 2026
$8.0M
PHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1M
Genetic network analysis of cancer targetsU01CA176287 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISS, WILLIAM A · 2013 to 2016
$1.2M
Genetic analysis of ras mutation specificity in skin and lung cancerR01CA184510 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALMAIN, ALLAN · 2015 to 2017
$1.1M
Examining the impact of the obesity-inflammation axis on cancer by genomic and transcriptomic profilingF32CA232635 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, YUN ROSE · 2018 to 2020
$202k
Genetic factors influencing the immune response to carcinomas in skin cancerF31CA180715 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HALLIWILL, KYLE DAVID · 2013 to 2014
$72k
Cancer Research UK 12401Cancer Research UK 21717NCI NIH HHS F31 CA180715NCI NIH HHS F32 CA232635NCI NIH HHS R01 CA184510NCI NIH HHS R35 CA210018NCI NIH HHS U01 CA084244NCI NIH HHS U01 CA176287NIGMS NIH HHS T32 GM007175
6 · The paper itself

Abstract

Ionising radiation (IR) is a recognised carcinogen responsible for cancer development in patients previously treated using radiotherapy, and in individuals exposed as a result of accidents at nuclear energy plants. However, the mutational signatures induced by distinct types and doses of radiation are unknown. Here, we analyse the genetic architecture of mammary tumours, lymphomas and sarcomas induced by high (

Indexed as

AnimalsCarcinogenesisDNA DamageDNA Mutational AnalysisDose-Response Relationship, RadiationFemaleGene AmplificationGenomic InstabilityGerm-Line MutationHumansMaleMiceMice, KnockoutNeoplasms, Radiation-InducedPoint MutationProto-Oncogene Proteins c-metProto-Oncogene Proteins c-metTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID31959748
PMCPMC6971050
OpenAlexW2998945864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.