Observational studyDrug metabolism and disposition: the biological fate of chemicals2020
Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine.
Erratum issuedOpen access · bronzeAbstract readObservational Study
In one paragraph
Observational study in Drug metabolism and disposition: the biological fate of chemicals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 99 citations in OpenAlex.
- Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers.Clinical pharmacology and therapeutics · 2022Trial
- Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers.Clinical and translational science · 2021Trial
- Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers.British journal of clinical pharmacology · 2020Trial
- Overlooked aspects of scaling enzyme activity through abundance across tissues and individuals: Insights from kDrug metabolism and disposition: the biological fate of chemicals · 2026Article
- Differential Tissue Abundance of Membrane-Bound Drug Metabolizing Enzymes and Transporter Proteins by Global Proteomics.Drug metabolism and disposition: the biological fate of chemicals · 2024Article
- Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).European journal of drug metabolism and pharmacokinetics · 2024Article
- In Vitro to In Vivo Scalars for Drug Clearance in Nonalcoholic Fatty Liver and Steatohepatitis.Drug metabolism and disposition: the biological fate of chemicals · 2024Article
- Membrane transporters in drug development and as determinants of precision medicine.Nature reviews. Drug discovery · 2024Review
- Simultaneous Prediction Method for Intestinal Absorption and Metabolism Using the Mini-Ussing Chamber System.Pharmaceutics · 2023Review
- Oral Pathogenic Bacteria and the Oral-Gut-Liver Axis: A New Understanding of Chronic Liver Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Developing a mechanistic understanding of the nonlinear pharmacokinetics of letermovir and prospective drug interaction with everolimus using physiological-based pharmacokinetic modeling.Clinical and translational science · 2023Article
- An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics.Science advances · 2023Article
- Article
- Developing a Knowledge Graph for Pharmacokinetic Natural Product-Drug Interactions.Journal of biomedical informatics · 2023Article
- Prediction of trough concentration and ALK occupancy in plasma and cerebrospinal fluid using physiologically based pharmacokinetic modeling of crizotinib, alectinib, and lorlatinib.Frontiers in pharmacology · 2023Article
- Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis.Frontiers in oncology · 2023Article
- Recent advances in the ontogeny of drug disposition.British journal of clinical pharmacology · 2022Review
- Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development.Acta pharmaceutica Sinica. B · 2022Review
- Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series.Pharmaceutics · 2022Article
- Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity.Clinical pharmacology and therapeutics · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Narciso CoutoCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.) narciso.couto@manchester.ac.uk.ORCID 0000-0001-7565-4357
Zubida M Al-MajdoubCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).
Stephanie GibsonCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).
Pamela J DaviesCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).
Brahim AchourCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).ORCID 0000-0002-2595-5626
Matthew D HarwoodCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).ORCID 0000-0002-3481-8201
Gordon CarlsonCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).
Jill BarberCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).
Amin Rostami-HodjeganCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.) amin.rostami@manchester.ac.uk.ORCID 0000-0003-3917-844X
Geoffrey WarhurstCentre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom (N.C., Z.M.A.-M., B.A., J.B., A.R.-H.); Gut Barrier Group, Inflammation and Repair, University of Manchester, Salford Royal NHS Trust, Salford, United Kingdom (S.G., P.J.D., G.C., G.W.); and Certara UK Limited (Simcyp Division), Sheffield, United Kingdom (M.D.H., A.R.-H.).
Salford Royal NHS Foundation Trust · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
The levels of drug-metabolizing enzymes (DMEs) and transporter proteins in the human intestine are pertinent to determine oral drug bioavailability. Despite the paucity of reports on such measurements, it is well recognized that these values are essential for translating in vitro data on drug metabolism and transport to predict drug disposition in gut wall. In the current study, clinically relevant DMEs [cytochrome P450 (P450) and uridine 5'-diphospho-glucuronosyltransferase (UGT)] and drug transporters were quantified in total mucosal protein preparations from the human jejunum (
Indexed as
Administration, OralAdolescentAdultAgedAged, 80 and overBiological AvailabilityCytochrome P-450 Enzyme SystemDrug InteractionsFemaleGlucuronosyltransferaseHumansJejunumMaleMetabolic Clearance RateMiddle AgedModels, BiologicalCytochrome P-450 Enzyme SystemGlucuronosyltransferaseOrganic Anion Transporters
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.