Evidence map›Paper›PMID 31959630›Full record

ArticleThe Journal of biological chemistry2020

Von Hippel-Lindau tumor suppressor (VHL) stimulates TOR signaling by interacting with phosphoinositide 3-kinase (PI3K).

Sun-Hong Hwang, Sunhoe Bang, Wonho Kim, Jongkyeong Chung

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Lighting up Nobel Prize-winning studies with protein intrinsic disorder.Cellular and molecular life sciences : CMLS · 2022
    Review
  2. Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?International journal of molecular sciences · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sun-Hong HwangSchool of Biological Sciences, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea.
Sunhoe BangSchool of Biological Sciences, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea.
Wonho KimInstitute of Molecular Biology and Genetics, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea.
Jongkyeong ChungSchool of Biological Sciences, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-Gu, Seoul 08826, Republic of Korea. Electronic address: jkc@snu.ac.kr.
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell growth is positively controlled by the phosphoinositide 3-kinase (PI3K)-target of rapamycin (TOR) signaling pathway under conditions of abundant growth factors and nutrients. To discover additional mechanisms that regulate cell growth, here we performed RNAi-based mosaic analyses in the

Indexed as

Signal TransductionAnimalsBody SizeCarrier ProteinsCell SizeDrosophila melanogasterDrosophila ProteinsHEK293 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitMicePhosphatidylinositol 3-KinaseProtein BindingReceptor Protein-Tyrosine KinasesCarrier ProteinsDrosophila ProteinsHypoxia-Inducible Factor 1, alpha SubunitPhosphatidylinositol 3-KinaseReceptor Protein-Tyrosine Kinasestor protein, DrosophilaVhl protein, DrosophilaAkt PKBcell sizemetabolic regulationnutrient sensingp110phosphatidylinositide 3-kinase (PI 3-kinase)S6 kinasetarget of rapamycin (TOR)von Hippel–Lindau (VHL)

Identifiers

PMID31959630
PMCPMC7039557
OpenAlexW3002686744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.