ArticleFluids and barriers of the CNS2020
Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients.
Article in Fluids and barriers of the CNS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Central Nervous System Biodistribution and Pharmacokinetics of Radiolabeled Tofersen in Rodents, Nonhuman Primates, and Humans.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- On reduced-order modeling of drug dispersion in the spinal canal.Fluids and barriers of the CNS · 2025Article
- Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma.Communications medicine · 2025Article
- Cerebrospinal fluid dynamics and subarachnoid space occlusion following traumatic spinal cord injury in the pig: an investigation using magnetic resonance imaging.Fluids and barriers of the CNS · 2025Article
- Article
- Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow.Fluids and barriers of the CNS · 2024Article
- Decoupling Between Brain Activity and Cerebrospinal Fluid Movement in Neurological Disorders.Journal of magnetic resonance imaging : JMRI · 2024Review
- Resting-state functional MRI of the nose as a novel investigational window into the nervous system.Scientific reports · 2024Article
- Impairment of spinal CSF flow precedes immune cell infiltration in an active EAE model.Journal of neuroinflammation · 2024Article
- Stationary flow driven by non-sinusoidal time-periodic pressure gradients in wavy-walled channels.Applied mathematical modelling · 2023Article
- Syringomyelia: A New Phenotype ofBrain & NeuroRehabilitation · 2023Article
- Article
- Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging.Fluids and barriers of the CNS · 2023Article
- Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology.Fluids and barriers of the CNS · 2022Article
- Dynamic mechanical interaction between injection liquid and human tissue simulant induced by needle-free injection of a highly focused microjet.Scientific reports · 2021Article
- Soft Capsule Magnetic Millirobots for Region-Specific Drug Delivery in the Central Nervous System.Frontiers in robotics and AI · 2021Article
- Defining novel functions for cerebrospinal fluid in ALS pathophysiology.Acta neuropathologica communications · 2020Review
- In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy.Fluids and barriers of the CNS · 2020Article
- CNS fluid and solute movement: physiology, modelling and imaging.Fluids and barriers of the CNS · 2020Article
- Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDeveloping novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due to close proximity of cerebrospinal fluid (CSF) to affected tissues. Development of effective intrathecal pharmaceuticals will rely on accurate models of how drugs are dispersed in the CSF. Therefore, a method to quantify these dynamics and a characterization of differences across disease states is needed.
methodsComplete intrathecal 3D CSF geometry and CSF flow velocities at six axial locations in the spinal canal were collected by T2-weighted and phase-contrast MRI, respectively. Scans were completed for eight people with ALS and ten healthy controls. Manual segmentation of the spinal subarachnoid space was performed and coupled with an interpolated model of CSF flow within the spinal canal. Geometric and hydrodynamic parameters were then generated at 1 mm slice intervals along the entire spine. Temporal analysis of the waveform spectral content and feature points was also completed.
resultsComparison of ALS and control groups revealed a reduction in CSF flow magnitude and increased flow propagation velocities in the ALS cohort. Other differences in spectral harmonic content and geometric comparisons may support an overall decrease in intrathecal compliance in the ALS group. Notably, there was a high degree of variability between cases, with one ALS patient displaying nearly zero CSF flow along the entire spinal canal.
conclusionWhile our sample size limits statistical confidence about the differences observed in this study, it was possible to measure and quantify inter-individual and cohort variability in a non-invasive manner. Our study also shows the potential for MRI based measurements of CSF geometry and flow to provide information about the hydrodynamic environment of the spinal subarachnoid space. These dynamics may be studied further to understand the behavior of CSF solute transport in healthy and diseased states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.