Evidence map›Paper›PMID 31959117›Full record

ArticleBMC gastroenterology2020

Analysis of the relationship between MIR155HG variants and gastric Cancer susceptibility.

Wenjing Zou, Xu Li, Cheng Li, Dan Liu, Yanyan Lv, Ying Yang, Nan Ye, Dan Guo, Shuixiang He

Open access · goldAbstract read
In one paragraph

Article in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Analysis ofNon-coding RNA research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenjing ZouDepartment of gastroenterology, First Affiliate Hospital of Xi'an JiaoTong University, #227 West Yanta Road, Xi'an, 710061, Shaanxi Province, China.
Xu LiDepartment of The First of Internal Medicine, Tumor Hospital of Shannxi Province, The Affiliate Hospital of Medical College of Xi'an JiaoTong Univrsity, Xi'an, 710061, Shannxi, China.
Cheng LiDepartment of Geriatrics, Xi'an Central Hospital, Xi'an, 710003, Shannxi, China.
Dan LiuDepartment of Rheumatology, Xi'an No5 Hospital, Xi'an, 710082, Shannxi, China.
Yanyan LvDepartment of Rheumatology, Xi'an No5 Hospital, Xi'an, 710082, Shannxi, China.
Ying YangDepartment of The Second of Internal Medicine, Xi'an No5 Hospital, Xi'an, 710082, Shannxi, China.
Nan YeDepartment of The Second of Internal Medicine, Xi'an No5 Hospital, Xi'an, 710082, Shannxi, China.
Dan GuoDepartment of gastroenterology, First Affiliate Hospital of Xi'an JiaoTong University, #227 West Yanta Road, Xi'an, 710061, Shaanxi Province, China.
Shuixiang HeDepartment of gastroenterology, First Affiliate Hospital of Xi'an JiaoTong University, #227 West Yanta Road, Xi'an, 710061, Shaanxi Province, China. dyyyjxk@mail.xjtu.edu.cn.
First Affiliated Hospital of Xi'an Jiaotong University · CNXian Central Hospital · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer risk. MATERIALS &

methodsA total of 506 gastric cancer patients and 500 healthy controls were enrolled in this study. Genotypes were examined with the MassARRAY platform and data management and analysis were conducted with the Typer Software. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated with logistic regression adjusting for age and gender to evaluate the associations between SNPs with gastric cancer in genetic model analysis.

resultsThe "CC" genotype of rs4143370 decreased the risk of gastric cancer in genotype model (p = 0.020) and recessive model (p = 0.018). Inversely, the "CC" genotype of rs1893650 increased the risk of gastric cancer in genotype model (p = 0.023) and recessive model (p = 0.014). Stratified analysis showed that rs11911469 was associated with an increased risk of gastric cancer only among the male group in the dominant model (p = 0.039) and additive model (p = 0.030). The haplotype analysis showed a strong linkage disequilibrium among these six SNPs (rs4143370, rs77699734, rs11911469, rs1893650, rs34904192 and rs928883).

conclusionThis study confirmed the relationship between SNPs of MIR155HG and the gastric cancer risk among the Chinese Han population. Our data may provide a new perspective to understand the aetiology of gastric cancer.

Indexed as

Genetic Predisposition to DiseaseAsian PeopleComputational BiologyFemaleGenetic Association StudiesGenotypeHaplotypesHumansLinkage DisequilibriumMaleMicroRNAsMiddle AgedOdds RatioPolymorphism, Single NucleotideRisk FactorsStomach NeoplasmsMicroRNAsMIRN155 microRNA, humanCase-control studyGastric cancerMIR155HGSingle nucleotide polymorphism

Identifiers

PMID31959117
PMCPMC6972026
OpenAlexW3004520195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.