ArticleBMC genomics2020
Differential basal expression of immune genes confers Crassostrea gigas resistance to Pacific oyster mortality syndrome.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Embryonic Hormetic Priming Modulates Later-Life Thermal Tolerance.Ecology and evolution · 2026Article
- Dynamics of Bacterial and Vibrio Communities in Blacklip Rock Oysters in the Seasonal Tropics.Microbial ecology · 2025Article
- Reproductive aging weakens offspring survival and constrains the telomerase response to herpesvirus in Pacific oysters.Science advances · 2024Article
- A core of functional complementary bacteria infects oysters in Pacific Oyster Mortality Syndrome.Animal microbiome · 2023Article
- Resistance ofFrontiers in immunology · 2023Article
- UnderstandingFrontiers in genetics · 2023Article
- Understanding the Dynamic of POMS Infection and the Role of Microbiota Composition in the Survival of Pacific Oysters, Crassostrea gigas.Microbiology spectrum · 2022Article
- ADAR-Editing during Ostreid Herpesvirus 1 Infection inmSphere · 2022Article
- Genetic diversity and connectivity of the Ostreid herpesvirus 1 populations in France: A first attempt to phylogeographic inference for a marine mollusc disease.Virus evolution · 2022Article
- Synergistic Interaction of Low Salinity Stress WithFrontiers in immunology · 2022Article
- Effect of Different Species ofToxins · 2021Article
- Potential of genomic technologies to improve disease resistance in molluscan aquaculture.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- The Pacific Oyster Mortality Syndrome, a Polymicrobial and Multifactorial Disease: State of Knowledge and Future Directions.Frontiers in immunology · 2021Review
- Transcriptomics Analysis and Re-sequencing Reveal the Mechanism Underlying the Thermotolerance of an Artificial Selection Population of the Pacific Oyster.Frontiers in physiology · 2021Article
- High temperature induces transcriptomic changes inThe Journal of experimental biology · 2020Article
- Contribution of Viral Genomic Diversity to Oyster Susceptibility in the Pacific Oyster Mortality Syndrome.Frontiers in microbiology · 2020Article
- Functional Insights From the Evolutionary Diversification of Big Defensins.Frontiers in immunology · 2020Review
- Comparative Proteomics of Ostreid Herpesvirus 1 and Pacific Oyster Interactions With Two Families Exhibiting Contrasted Susceptibility to Viral Infection.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAs a major threat to the oyster industry, Pacific Oyster Mortality Syndrome (POMS) is a polymicrobial disease affecting the main oyster species farmed across the world. POMS affects oyster juveniles and became panzootic this last decade, but POMS resistance in some oyster genotypes has emerged. While we know some genetic loci associated with resistance, the underlying mechanisms remained uncharacterized. So, we developed a comparative transcriptomic approach using basal gene expression profiles between different oyster biparental families with contrasted phenotypes when confronted to POMS (resistant or susceptible).
resultsWe showed that POMS resistant oysters show differential expression of genes involved in stress responses, protein modifications, maintenance of DNA integrity and repair, and immune and antiviral pathways. We found similarities and clear differences among different molecular pathways in the different resistant families. These results suggest that the resistance process is polygenic and partially varies according to the oyster genotype.
conclusionsWe found differences in basal expression levels of genes related to TLR-NFκB, JAK-STAT and STING-RLR pathways. These differences could explain the best antiviral response, as well as the robustness of resistant oysters when confronted to POMS. As some of these genes represent valuable candidates for selective breeding, we propose future studies should further examine their function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.