ArticleBMC genomics2020
Comprehensive profiling of alternative splicing landscape during cold acclimation in tea plant.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 80 citations in OpenAlex.
- Splicing Factors in Plant Abiotic Stress Responses: Regulatory Mechanisms and Perspectives.Plants (Basel, Switzerland) · 2026Review
- Genome-wide identification of the AP2/ERF gene family and its alternative splicing to reveal their expression profiles in different tissues of Rosa roxburghii.BMC plant biology · 2026Article
- Comparative proteomics analysis of contrasting Camellia sinensis genotypes exposed to cold acclimation and freezing stress.BMC plant biology · 2025Article
- The Arabidopsis thaliana core splicing factor PORCUPINE/SmE1 requires intron-mediated expression.PloS one · 2025Article
- Splicing and expression dynamics of SR genes in hot pepper (Frontiers in plant science · 2024Article
- Full-length single-molecule sequencing uncovers novel insight into the global landscape of the cold stress response in trifoliate orange (Frontiers in plant science · 2024Article
- Full-length transcriptome sequencing provides insights into alternative splicing under cold stress in peanut.Frontiers in plant science · 2024Article
- The subgenome Saccharum spontaneum contributes to sugar accumulation in sugarcane as revealed by full-length transcriptomic analysis.Journal of advanced research · 2023Article
- Alternative Splicing under Cold Stress in Paper Mulberry.Plants (Basel, Switzerland) · 2023Article
- A geraniol synthase regulates plant defense via alternative splicing in tea plants.Horticulture research · 2023Article
- RNA Methylome Reveals the mGenomics, proteomics & bioinformatics · 2023Article
- Genome-wide identification of the PYL gene family of tea plants (Camellia sinensis) revealed its expression profiles under different stress and tissues.BMC genomics · 2023Article
- Light Intensity Regulates Low-Temperature Adaptability of Tea Plant through ROS Stress and Developmental Programs.International journal of molecular sciences · 2023Article
- De novo full length transcriptome analysis of a naturally caffeine-free tea plant reveals specificity in secondary metabolic regulation.Scientific reports · 2023Article
- Alternative Splicing in the Regulatory Circuit of Plant Temperature Response.International journal of molecular sciences · 2023Review
- Comparative Analysis of Alternative Splicing in Two Contrasting Apple Cultivars Defense againstInternational journal of molecular sciences · 2022Article
- Combined Metabolomic and Transcriptomic Analysis Reveals Allantoin Enhances Drought Tolerance in Rice.International journal of molecular sciences · 2022Article
- A Global Analysis of Alternative Splicing ofCurrent genomics · 2022Article
- Alternative Splicing and Its Roles in Plant Metabolism.International journal of molecular sciences · 2022Review
- Abiotic stress responses in plants.Nature reviews. Genetics · 2022Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlternative splicing (AS) may generate multiple mRNA splicing isoforms from a single mRNA precursor using different splicing sites, leading to enhanced diversity of transcripts and proteins. AS has been implicated in cold acclimation by affecting gene expression in various ways, yet little information is known about how AS influences cold responses in tea plant (Camellia sinensis).
resultsIn this study, the AS transcriptional landscape was characterized in the tea plant genome using high-throughput RNA-seq during cold acclimation. We found that more than 41% (14,103) of genes underwent AS events. We summarize the possible existence of 11 types of AS events, including the four common types of intron retention (IR), exon skipping (ES), alternative 5' splice site (A5SS), and alternative 3' splice site (A3SS); of these, IR was the major type in all samples. The number of AS events increased rapidly during cold treatment, but decreased significantly following de-acclimation (DA). It is notable that the number of differential AS genes gradually increased during cold acclimation, and these genes were enriched in pathways relating to oxidoreductase activity and sugar metabolism during acclimation and de-acclimation. Remarkably, the AS isoforms of bHLH transcription factors showed higher expression levels than their full-length ones during cold acclimation. Interestingly, the expression pattern of some AS transcripts of raffinose and sucrose synthase genes were significantly correlated with sugar contents.
conclusionOur findings demonstrated that changes in AS numbers and transcript expression may contribute to rapid changes in gene expression and metabolite profile during cold acclimation, suggesting that AS events play an important regulatory role in response to cold acclimation in tea plant.
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