ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2020
Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Tartrazine clearing of the tympanic membrane for improved visualization of the middle ear.Biomedical optics express · 2026Article
- Middle Ear Bacterial Colonization and Recurrence of Radiation-Induced OME: A Prospective Study.The Laryngoscope · 2026Observational
- Diagnosis of tympanic effusions using hyperspectral imaging to prevent unnecessary paracentesis procedures.BMC medical imaging · 2026Article
- Optical Coherence Tomography as an Emerging Technique for Identifying Pediatric Middle Ear Effusion.The Laryngoscope · 2026Article
- Quantitative measurement of tympanic membrane structure and symmetry with optical coherence tomography in normal human subjects.Journal of biomedical optics · 2025Article
- Optical Coherence Tomography Imaging and Angiography of Skull Base Tumors Presenting as a Middle Ear Mass in Clinic.Diagnostics (Basel, Switzerland) · 2025Article
- Optical coherence tomography otoscope for imaging of tympanic membrane and middle ear pathology.Journal of biomedical optics · 2024Article
- Development and Validation of an Automated Classifier to Diagnose Acute Otitis Media in Children.JAMA pediatrics · 2024Article
- In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023Observational
- Transmastoid Ultrasound Detection of Middle Ear Effusion and Its Association with Clinical Audiometric Tests.Life (Basel, Switzerland) · 2022Article
- New Approaches and Technologies to Improve Accuracy of Acute Otitis Media Diagnosis.Diagnostics (Basel, Switzerland) · 2021Review
- Intelligent smartphone-based multimode imaging otoscope for the mobile diagnosis of otitis media.Biomedical optics express · 2021Article
- Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach.Scientific reports · 2021Article
- Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections.Biosensors · 2021Article
- In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography.Journal of biophotonics · 2021Article
- Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy.Scientific reports · 2021Article
- Advances in Optical Detection of Human-Associated Pathogenic Bacteria.Molecules (Basel, Switzerland) · 2020Review
- Optical Identification of Middle Ear Infection.Molecules (Basel, Switzerland) · 2020Review
- New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2019.OTO openReview
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo determine the feasibility of detecting and differentiating middle ear effusions (MEEs) using an optical coherence tomography (OCT) otoscope. STUDY
designCross-sectional study.
settingUS tertiary care children's hospital. SUBJECTS AND
methodsSeventy pediatric patients undergoing tympanostomy tube placement were preoperatively imaged using an OCT otoscope. A blinded reader quiz was conducted using 24 readers from 4 groups of tiered medical expertise. The primary outcome assessed was reader ability to detect presence/absence of MEE. A secondary outcome assessed was reader ability to differentiate serous vs nonserous MEE.
resultsOCT image data sets were analyzed from 45 of 70 total subjects. Blinded reader analysis of an OCT data subset for detection of MEE resulted in 90.6% accuracy, 90.9% sensitivity, 90.2% specificity, and intra/interreader agreement of 92.9% and 87.1%, respectively. Differentiating MEE type, reader identification of nonserous MEE had 70.8% accuracy, 53.6% sensitivity, 80.1% specificity, and intra/interreader agreement of 82.9% and 75.1%, respectively. Multivariate analysis revealed that age was the strongest predictor of OCT quality. The mean age of subjects with quality OCT was 5.01 years (n = 45), compared to 2.54 years (n = 25) in the remaining subjects imaged (
conclusionOCT otoscopy shows promise for facilitating accurate MEE detection. The imageability with the prototype device was affected by age, with older children being easier to image, similar to current ear diagnostic technologies.
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