Evidence map›Paper›PMID 31959038›Full record

ArticleCell cycle (Georgetown, Tex.)2020

WIP1 dephosphorylation of p27

Byung-Kwon Choi, Kenichiro Fujiwara, Tajhal Dayaram, Yolanda Darlington, Joshua Dickerson, Margaret A Goodell, Lawrence A Donehower

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Regulation of p27Biomolecules · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Byung-Kwon ChoiDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Kenichiro FujiwaraDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-9677-0637
Tajhal DayaramDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Yolanda DarlingtonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Joshua DickersonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Margaret A GoodellMolecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Lawrence A DonehowerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · US

Funding

PPM1D in Clonal Hematopoiesis and MalignanciesR01CA237291 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL, Koichi Takahashi · 2019 to 2026
$3.7M
Clonal Hematopoiesis, Aging and Genome Stability in PPM1D MutantsU01CA236972 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2019 to 2020
$240k
The Role of WIP1 in Clonal HematopoiesisF30DK116428 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HSU, JOANNE INO · 2017 to 2019
$118k
NCI NIH HHS R01 CA237291NCI NIH HHS U01 CA236972NIDDK NIH HHS F30 DK116428
6 · The paper itself

Abstract

The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibitor p27

Indexed as

Ataxia Telangiectasia Mutated ProteinsCell ProliferationCyclin-Dependent Kinase Inhibitor p27HEK293 CellsHumansMCF-7 CellsMutationPhosphopeptidesPhosphorylationProtein Phosphatase 2CProtein StabilityReproducibility of ResultsSerineTumor Stem Cell AssayAtaxia Telangiectasia Mutated ProteinsATM protein, humanATR protein, humanCyclin-Dependent Kinase Inhibitor p27PhosphopeptidesPPM1D protein, humanProtein Phosphatase 2CSerineATMCDKN1Bp27Kip1PPM1DSerine 140WIP1

Identifiers

PMID31959038
PMCPMC7100888
OpenAlexW3001135622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.