Evidence map›Paper›PMID 31959027›Full record

ReviewExpert opinion on biological therapy2020

Prospects of biological and synthetic pharmacotherapies for glioblastoma.

David B Altshuler, Padma Kadiyala, Felipe J Nuñez, Fernando M Nuñez, Stephen Carney, Mahmoud S Alghamri, Maria B Garcia-Fabiani, Antonela S Asad, Alejandro J Nicola Candia, Marianela Candolfi and 5 more

Open access · greenAbstract readReview
In one paragraph

Review in Expert opinion on biological therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Glioblastoma Treatment: State-of-the-Art and Future Perspectives.International journal of molecular sciences · 2022
    Review
  6. Therapeutic Options in Neuro-Oncology.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Current Approaches for Glioma Gene Therapy and Virotherapy.Frontiers in molecular neuroscience · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

David B AltshulerDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Padma KadiyalaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Felipe J NuñezDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Fernando M NuñezDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Stephen CarneyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Mahmoud S AlghamriDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Maria B Garcia-FabianiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Antonela S AsadDepartamento de Biología Celular e Histología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0002-1234-7250
Alejandro J Nicola CandiaDepartamento de Biología Celular e Histología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Marianela CandolfiDepartamento de Biología Celular e Histología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0002-0843-6568
Joerg LahannDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
James J MoonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Anna SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8023-8080
Pedro R LowensteinDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Maria G CastroDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USUniversidad de Buenos Aires · AR

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and LeukodystrophiesR01NS076991 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Guangping Gao · 2012 to 2026
$5.7M
Immune-suppressive Myeloid Cells in the Glioma Microenvironment: Signaling Mechanisms and Novel Therapeutic StrategiesR37NS094804 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2015 to 2021
$2.9M
Novel combined immunotherapeutic strategies for glioma: using pet dogs as a large animal spontaneous modelU01CA224160 · NCI · UNIVERSITY OF MINNESOTA · PI PLUHAR, GRACE ELIZABETH · 2017 to 2021
$2.7M
Neuroimmunology of Malignant Brain Tumors: Innate MechanismsR01NS096756 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2016 to 2020
$2.1M
Interactions between the tumor cells and the neuro-immune microenvironment in mutant IDH1 gliomas: implications for therapeuticsR01NS105556 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2018 to 2021
$1.9M
Mechanisms of glioma growth and invasion novel therapeutic strategiesR01NS082311 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOWENSTEIN, PEDRO R. · 2013 to 2017
$1.7M
Tuning Biomaterials-immune cell interactions for treatment of glioblastoma multiformeR01EB022563 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2016 to 2019
$1.7M
Immune-mediated therapies in a genetically engineered murine model of diffuse intrinsic pontine gliomaR21NS107894 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2019 to 2019
$442k
HDL-Loaded Nanoparticles for Glioma TherapeuticsR21NS091555 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G · 2015 to 2016
$427k
NCI NIH HHS P30 CA046592NCI NIH HHS T32 CA009676NCI NIH HHS U01 CA224160NIBIB NIH HHS R01 EB022563NINDS NIH HHS R01 NS076991NINDS NIH HHS R01 NS082311NINDS NIH HHS R01 NS096756NINDS NIH HHS R01 NS105556NINDS NIH HHS R21 NS091555NINDS NIH HHS R21 NS107894NINDS NIH HHS R37 NS094804
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain NeoplasmsCancer VaccinesGenetic TherapyGlioblastomaHumansImmune Checkpoint InhibitorsImmunotherapy, AdoptiveIsocitrate DehydrogenaseNanomedicineOncolytic VirotherapyCancer VaccinesImmune Checkpoint InhibitorsIsocitrate Dehydrogenasegene therapyGliomaIDH1 mutationimmune checkpoint inhibitorsimmunotherapy

Identifiers

PMID31959027
PMCPMC7059118
OpenAlexW3003087588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.