Evidence map›Paper›PMID 31959014›Full record

ArticleCirculation. Heart failure2020

Low- Versus Moderate-Sodium Diet in Patients With Recent Hospitalization for Heart Failure: The PROHIBIT (Prevent Adverse Outcomes in Heart Failure by Limiting Sodium) Pilot Study.

Andreas Kalogeropoulos, Lampros Papadimitriou, Vasiliki V Georgiopoulou, Sandra B Dunbar, Hal Skopicki, Javed Butler

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02467296 (Rationale and Design of the PRevent Adverse Outcomes in Heart faIlure By limITing Sodium Study), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02467296 nacompletednot on this map

Rationale and Design of the PRevent Adverse Outcomes in Heart faIlure By limITing Sodium Study

TypeinterventionalSponsorStony Brook UniversityRan2015 to 2018Enrolled27ConditionsHeart FailureArmsDietary plan with controlled amount of Sodium
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Safety and Efficacy of Salt Restriction Across the Spectrum of Heart Failure.Journal of cardiovascular development and disease · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Sodium Intake and Heart Failure.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Andreas KalogeropoulosDivision of Cardiology, Department of Medicine, Stony Brook University, NY (A.K., L.P., H.S.).
Lampros PapadimitriouDivision of Cardiology, Department of Medicine, Stony Brook University, NY (A.K., L.P., H.S.).
Vasiliki V GeorgiopoulouDepartment of Medicine (V.V.G.), Emory University, Atlanta, GA.
Sandra B DunbarSchool of Nursing (S.B.D.), Emory University, Atlanta, GA.
Hal SkopickiDivision of Cardiology, Department of Medicine, Stony Brook University, NY (A.K., L.P., H.S.).
Javed ButlerDepartment of Medicine, University of Mississippi, Jackson (L.P., J.B.).
Stony Brook University Hospital · USEmory University · USUniversity of Mississippi · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Dietary Sodium Intake and Outcomes in Heart Failure: A Clinical Trial Pilot StudyR34HL119773 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BUTLER, JAVED · 2014 to 2015
$563k
NHLBI NIH HHS R34 HL119773NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundWe conducted a pilot study to assess feasibility, on-study retention, trends in natriuretic peptide levels, quality of life, and safety of a 12-week feeding trial with 1500- versus 3000-mg daily sodium meals in high-risk patients with heart failure.

methodsOf 196 patients with recent (≤2 weeks) hospitalization for heart failure, ejection fraction ≤40%, on optimal medical therapy, functionally independent, and able to communicate, 83 (47%) consented to participate. Of these, 27 (age, 62±11 years; 22 men; 20 white; ejection fraction, 26±8%) had 24-hour urine sodium ≥3000 mg and agreed to randomly receive either 1500-mg (N=12) or 3000-mg (N=15) sodium meals.

resultsOn-study retention at 12 weeks was 77% (82% versus 73%;

conclusionsEven with prepared meals, investigating optimal dietary sodium in heart failure comes with challenges, including need for extensive screening, reluctance to participate, and compliance issues. Because both diets reduced urinary sodium without adverse safety or quality of life signals, a larger trial, with modifications to improve participation and compliance, would be ethical and feasible. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT02467296.

Indexed as

AgedFemaleHeart FailureHospitalizationHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPilot ProjectsQuality of LifeSodiumStroke VolumeNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Sodiumheart failurehospitalizationquality of lifesodium, dietary

Identifiers

PMID31959014
PMCPMC7233690
OpenAlexW3002693344

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.