Evidence map›Paper›PMID 31958913›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2020

Mismatch Negativity Indices as a Prognostic Factor for Remission in Schizophrenia.

Ji Sun Kim, Young Joon Kwon, Hwa Young Lee, Ho-Sung Lee, Sungkean Kim, Se-Hoon Shim

Abstract read
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Electrophysiological Changes Related to Childhood Trauma in Patients with Major Depressive Disorder: An Event-related Potential Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ji Sun KimDepartments of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0003-2472-4591
Young Joon KwonDepartments of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0001-9340-0895
Hwa Young LeeDepartments of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0002-2749-6232
Ho-Sung LeePulmonology and Allergy, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0001-6614-6465
Sungkean KimDepartment of Biomedical Engineering, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0003-4649-6112
Se-Hoon ShimDepartments of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.ORCID https://orcid.org/0000-0002-3137-6591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMismatch negativity (MMN) is known to be associated with neuro-cognition and functional outcomes. Remission and recovery rates are related to the neuro-cognition of patients with schizophrenia. The present study explored the relationship of MMN with remission in patients with schizophrenia.

methodsForty patients with schizophrenia were recruited and divided into two groups, with or without remission, according to the Remission in Schizophrenia Working Group criteria (RSWGcr). Symptom severity (Positive and Negative Syndrome Scale, PANSS), cognitive function, functional outcome, and MMN of the patients were evaluated. A regression analysis was used to identify the factors that significantly predicted symptom improvement and remission including MMN at frontal site assessed at baseline, and anticipated clinical variables as predictive factors.

resultsMMN amplitudes in frontal sites were further decreased in the groups without remission compared to the groups with remission. MMN amplitude was significantly correlated with measures of symptom change and functional outcome measurements in patients with schizophrenia. Regression analysis revealed that symptom severity and MMN significantly predicted remission in patients with schizophrenia. Symptom improvement significantly predicted PANSS at baseline, illness duration, and antipsychotic dose, as did MMN amplitude at frontal site.

conclusionOur results suggest that MMN reflected symptom improvement and remission in patients with schizophrenia. MMN indices appear to be promising candidates as predictive factors for schizophrenia remission.

Indexed as

Mismatch negativity.RemissionSchizophreniaSymptom improvement

Identifiers

PMID31958913
PMCPMC7006972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.