Evidence map›Paper›PMID 31958904›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2020

Plasma Risperidone-related Measures in Children and Adolescents with Oppositional Defiant/Conduct Disorders.

Daria Piacentino, Georgios D Kotzalidis, Georgios Schoretsanitis, Michael Paulzen, Ekkehard Haen, Simone Cappelletti, Giancarlo Giupponi, Michael Grözinger, Andreas Conca

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Daria PiacentinoSection on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse, Intramural Research Program, Nation.ORCID https://orcid.org/0000-0002-9991-7403
Georgios D KotzalidisNESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University of Rome, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy.ORCID https://orcid.org/0000-0002-0281-6324
Georgios SchoretsanitisDepartment of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.ORCID https://orcid.org/0000-0002-3851-4117
Michael PaulzenAlexianer Hospital Aachen, Aachen, Germany.ORCID https://orcid.org/0000-0003-4198-5160
Ekkehard HaenClinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.ORCID https://orcid.org/0000-0003-4430-4148
Simone CappellettiAnatomical, Histological, Forensic Medicine, and Orthopedic Sciences (SAIMLAL) Department, Sapienza University, Rome, Italy.ORCID https://orcid.org/0000-0002-9331-4273
Giancarlo GiupponiDepartment of Psychiatry, Central Hospital, Health Agency of South Tyrol, Bozen, Italy.ORCID https://orcid.org/0000-0001-6430-0000
Michael GrözingerDepartment of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0001-8700-9646
Andreas ConcaDepartment of Psychiatry, Central Hospital, Health Agency of South Tyrol, Bozen, Italy.ORCID https://orcid.org/0000-0003-4841-7510
RWTH Aachen University · DEAzienda Ospedaliera Sant'Andrea · ITNational Institute on Drug Abuse · USNorthwell Health · USSapienza University of Rome · ITUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTherapeutic drug monitoring helps clinicians in choosing the right drug and adjust its dose in specific patients. To this end, we aimed to assess time patterns of risperidone and its metabolite, 9-hydroxyrisperidone, in children and adolescents with oppositional defiant and/or conduct disorder.

methodsWe measured plasma concentrations of risperidone and 9-hydroxyrisperidone, their sum (active moiety, AM) and ratio, as well as plasma concentrations corrected for daily dose (C/D), from 140 children/adolescents with the above-mentioned disorders. We used Student's

resultsFemales had higher 9-hydroxyrisperidone and AM plasma concentrations than males (

conclusionClinicians prescribing risperidone need to consider sex, age, and weight, but not BMI when adjusting daily doses.

Indexed as

9-HydroxyrisperidoneConduct disorderOppositional defiant disorderRisperidoneTherapeutic drug monitoring.Youth

Identifiers

PMID31958904
PMCPMC7006987
OpenAlexW3001152309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.