ArticleInternational journal of sports medicine2020
Effect of Lower Body Negative Pressure on Phase I Cardiovascular Responses at Exercise Onset.
Article in International journal of sports medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Decreased exercise capacity in young athletes using self-adapted mouthguards.European journal of applied physiology · 2021Trial
- Effects of surgical face masks on cardiopulmonary parameters during steady state exercise.Scientific reports · 2020Trial
- Baroreflex dynamics during the rest to exercise transient in acute normobaric hypoxia in humans.European journal of applied physiology · 2024Article
- Dynamics of cardiovascular and baroreflex readjustments during a light-to-moderate exercise transient in humans.European journal of applied physiology · 2022Article
- Impact of Increasing Lower Body Negative Pressure and Its Abrupt Release on Left Ventricular Hemodynamics in Anesthetized Pigs.Journal of clinical medicine · 2022Article
- A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise.European journal of applied physiology · 2022Review
- Vagal blockade suppresses the phase I heart rate response but not the phase I cardiac output response at exercise onset in humans.European journal of applied physiology · 2021Article
- Baroreflex responses during dry resting and exercise apnoeas in air and pure oxygen.European journal of applied physiology · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
We hypothesised that vagal withdrawal and increased venous return interact in determining the rapid cardiac output (CO) response (phase I) at exercise onset. We used lower body negative pressure (LBNP) to increase blood distribution to the heart by muscle pump action and reduce resting vagal activity. We expected a larger increase in stroke volume (SV) and smaller for heart rate (HR) at progressively stronger LBNP levels, therefore CO response would remain unchanged. To this aim ten young, healthy males performed a 50 W exercise in supine position at 0 (Control), -15, -30 and -45 mmHg LBNP exposure. On single beat basis, we measured HR, SV, and CO. Oxygen uptake was measured breath-by-breath. Phase I response amplitudes were obtained applying an exponential model. LBNP increased SV response amplitude threefold from Control to -45 mmHg. HR response amplitude tended to decrease and prevented changes in CO response. The rapid response of CO explained that of oxygen uptake. The rapid SV kinetics at exercise onset is compatible with an increased venous return, whereas the vagal withdrawal conjecture cannot be dismissed for HR. The rapid CO response may indeed be the result of two independent yet parallel mechanisms, one acting on SV, the other on HR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.