Evidence map›Paper›PMID 31958755›Full record

ArticleiScience2020

Countermanding Perceptual Decision-Making.

Paul G Middlebrooks, Bram B Zandbelt, Gordon D Logan, Thomas J Palmeri, Jeffrey D Schall

Abstract read
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Factorial variation of saccade vigor with dual decision processes.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
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  6. Article
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  12. Article
  13. Dissociation of Medial Frontal β-Bursts and Executive Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paul G MiddlebrooksCenter for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Bram B ZandbeltCenter for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Gordon D LoganCenter for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Thomas J PalmeriCenter for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Jeffrey D SchallCenter for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN, USA. Electronic address: jeffrey.d.schall@vanderbilt.edu.

Funding

Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
NEURAL CONTROL OF VOLUNTARY MOVEMENTR01MH055806 · NIMH · VANDERBILT UNIVERSITY · PI SCHALL, JEFFREY D · 1996 to 2016
$5.2M
Stochastic Models of Visual SearchR01EY021833 · NEI · VANDERBILT UNIVERSITY · PI LOGAN, GORDON DENNIS, PALMERI, THOMAS · 2011 to 2023
$3.3M
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
Neuronal mechanisms of response inhibition during decision makingF32EY023526 · NEI · VANDERBILT UNIVERSITY · PI MIDDLEBROOKS, PAUL G · 2014 to 2016
$169k
NEI NIH HHS F32 EY023526NEI NIH HHS P30 EY008126NEI NIH HHS R01 EY021833NICHD NIH HHS U54 HD083211NIH HHS S10 OD023680NIMH NIH HHS R01 MH055806
6 · The paper itself

Abstract

We investigated whether a task requiring concurrent perceptual decision-making and response control can be performed concurrently, whether evidence accumulation and response control are accomplished by the same neurons, and whether perceptual decision-making and countermanding can be unified computationally. Based on neural recordings in a prefrontal area of macaque monkeys, we present behavioral, neural, and computational results demonstrating that perceptual decision-making of varying difficulty can be countermanded efficiently, that single prefrontal neurons instantiate both evidence accumulation and response control, and that an interactive race between stochastic GO evidence accumulators for each alternative and a distinct STOP accumulator fits countermanding choice behavior and replicates neural trajectories. Thus, perceptual decision-making and response control, previously regarded as distinct mechanisms, are actually aspects of a common neuro-computational mechanism supporting flexible behavior.

Indexed as

Behavioral NeuroscienceBiological SciencesCognitive NeuroscienceNeuroscienceSensory Neuroscience

Identifiers

PMID31958755
PMCPMC6992898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.