Evidence map›Paper›PMID 31958697›Full record

ArticleMolecular therapy. Nucleic acids2020

The MSC-Derived Exosomal lncRNA H19 Promotes Wound Healing in Diabetic Foot Ulcers by Upregulating PTEN via MicroRNA-152-3p.

Bo Li, Song Luan, Jing Chen, Yue Zhou, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong Bi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 7 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 7 syntheses or guidelines pooled it, 297 citations in OpenAlex.

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  6. Role of Exosomes in Dermal Wound Healing: A Systematic Review.The Journal of investigative dermatology · 2022
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  8. Review
  9. Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bo LiDepartment of Endocrinology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
Song LuanThe 2(nd) Department of General, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
Jing ChenThe 2(nd) Department of General, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
Yue ZhouThe 2(nd) Department of General, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
Tingting WangThe 2(nd) Department of General, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
Zhijuan LiThe 2(nd) Department of General, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.
Yili FuSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, People's Republic of China.
Aixia ZhaiDepartment of Microbiology, Harbin Medical University, Harbin 150081, People's Republic of China. Electronic address: aixiazhai@126.com.
Changlong BiDepartment of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, People's Republic of China. Electronic address: bichanglongdr@163.com.
Harbin Medical University · CNFourth Affiliated Hospital of Harbin Medical University · CNEighth Affiliated Hospital of Sun Yat-sen UniversityHarbin Institute of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have been reported to hold promise to accelerate the wound-healing process in diabetic foot ulcer (DFU) due to the multilineage differentiation potential. Hence, this study intended to explore the wound healing role of MSC-derived exosomes containing long noncoding RNA (lncRNA) H19 in DFU. lncRNA H19 was predicated to bind to microRNA-152-3p (miR-152-3p), which targeted phosphatase and tensin homolog (PTEN) deleted on chromosome ten. Fibroblasts in DFU samples exhibited highly expressed miR-152-3p and poorly expressed lncRNA H19 and PTEN, along with an activated phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt1) signaling pathway. The fibroblasts were cocultured with lncRNA H19-transfected MSCs and MSC-derived exosomes to assess the effect of the lncRNA H19/miR-152-3p/PTEN axis on the biological activities and inflammation in fibroblasts. Mouse models of DFU were developed by streptozotocin, which was injected with MSC-derived exosomes overexpressing lncRNA H19. lncRNA H19 in MSCs was transferred through exosomes to fibroblasts, the mechanism of which improved wound healing in DFU, corresponded to promoted fibroblast proliferation and migration, as well as suppressed apoptosis and inflammation. Wound healing in mice with DFU was facilitated following the injection of MSC-derived exosomes overexpressing lncRNA H19. Taken together, MSC-derived exosomal lncRNA H19 prevented the apoptosis and inflammation of fibroblasts by impairing miR-152-3p-mediated PTEN inhibition, leading to the stimulated wound-healing process in DFU.

Indexed as

diabetic foot ulcerexosomelong noncoding RNA H19mesenchymal stem cellsmicroRNA-152-3pPTEN

Identifiers

PMID31958697
PMCPMC7005423
OpenAlexW2995494472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.