ArticleDrug and alcohol dependence2020
Relationship between cannabis use frequency and major depressive disorder in adolescents: Findings from the National Survey on Drug Use and Health 2012-2017.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: A Systematic Review and Recommendations of Cannabis use in Bipolar Disorder and Major Depressive Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Pooled it
- Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use.Frontiers in public health · 2023Pooled it
- Binge alcohol and cannabis co-use associated with depression in Black men.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Association Between Legal Access to Medical Cannabis and Frequency of Non-Medical Prescription Opioid Use Among U.S. Adults.International journal of mental health and addiction · 2025Article
- An overview of the use of psychoactive substances among students at the University of Lille during the COVID-19 health crisis: Results of the PETRA study.Dialogues in clinical neuroscience · 2023Article
- Depression and suicide attempts in Chinese adolescents with mood disorders: the mediating role of rumination.European archives of psychiatry and clinical neuroscience · 2023Article
- Cannabis Use Is Associated With Depression Severity and Suicidality in the National Comorbidity Survey-Adolescent Supplement.JAACAP open · 2023Article
- Psychoactive substance use among students: A cross-sectional analysis.Fundamental & clinical pharmacology · 2022Article
- Review
- Ketamine use in relation to depressive symptoms among high school seniors.The American journal on addictions · 2022Article
- Association of Cannabis Use With Self-harm and Mortality Risk Among Youths With Mood Disorders.JAMA pediatrics · 2021Observational
- Article
- Cannabis Use, Cannabis Use Disorder, and Comorbid Psychiatric Illness: A Narrative Review.Journal of clinical medicine · 2020Review
- Incidence and Characteristics of Nonfatal Opioid Overdose Among Youths Aged 11 to 24 Years by Sex.JAMA network open · 2020Article
- A Multiple Correspondence Analysis of Patterns of CBD Use in Hemp and Marijuana Users.Frontiers in psychiatry · 2020Article
- Testing the Constraint Theory of Addiction: Cannabis Constraints Discriminate Users from Nonusers and Heavy from Light Users.Journal of addiction · 2020Article
- Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case-Control Study.Clinical psychology & psychotherapyArticle
- Associations Between Major Depressive Episodes, Sociodemographic Factors, and Past-Year Marijuana Use Among U.S. Adolescents: A Cross-Sectional Study.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCannabis use and major depressive disorder (MDD) are common and often co-morbid in adolescents, but the nature and directionality of the relationship between these two conditions remains obscure.
methodsWe examined results from the National Survey on Drug Use and Health. Weighted demographics were compared between adolescents with a history of cannabis use (N = 14,873) and never users (N = 73,079). Weighted logistic regression controlling for demographic variables and other substance use was used to determine the relationship between cannabis use frequency and MDD.
resultsAdolescents with any history of cannabis use had significantly higher rates of lifetime and past year MDD, MDD with severe role impairment, and past year suicide attempt (p < 0.001). Comparing use frequency groups in the adjusted model revealed that heavy users (weekly or greater use) had significantly lower predicted prevalence of lifetime and past year MDD, and past year MDD with severe role impairment compared to light users and those who used cannabis >1 year ago. Rates of reported past year suicide attempt did not differ significantly by cannabis use frequency.
conclusionsAdolescents with any cannabis use history have significantly higher rates of MDD. However, the directionality between frequency of use and MDD is counter to what was expected.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.