ArticleArchives of oral biology2020
Comparison of osteogenic and dentinogenic potentials of mice incisor and molar pulps in vitro.
Article in Archives of oral biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- MSC-derived small extracellular vesicles promote dental pulp repair by alleviating inflammation in pulpitis via AKT and p38 MAPK pathways.Stem cells (Dayton, Ohio) · 2026Article
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2 authors.
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Abstract
objectiveIn the present study, we compared the in vitro osteogenic and dentinogenic potential of pulp cells from incisors and molars.
designPrimary pulp cultures were established from DSPP-Cerulean/DMP1-Cherry and BSP-GFPtpz reporter mouse lines and processed for various assays.
resultsOur results showed marked differences in dentinogenic and osteogenic potentials of primary cultures from unerupted molars and incisors isolated from 5 to 7 days old pups. While primary cultures from both incisors and molars differentiated into odontoblasts and osteoblasts, cultures from molars differentiated into more DSPP-Cerulean + cells (∼5.5 %) compared to incisor cultures (∼0.7 %) at Day 14 and appear to be more committed to the odontogenic lineage. On the other hand, cultures from incisors show more differentiation into BSP-GFPtpz + cells (∼25 %) compared to molar cultures (∼16 %) and were more committed to the osteogenic lineage. Data were analyzed by Student's t-test and statistical significance was set at P ≤ 0.05.
conclusionSince in the dental pulp, MSCs are the primary source of progenitors capable of giving rise to osteoblasts and odontoblasts, our results provide evidence for differences in the commitment of MSCs in molars and incisors to the odontogenic and osteogenic lineages, respectively.
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