Evidence map›Paper›PMID 31958495›Full record

ReviewNeuroscience research2020

New frontiers in probing the dynamics of purinergic transmitters in vivo.

Zhaofa Wu, Yulong Li

Abstract readReview
In one paragraph

Review in Neuroscience research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Adenosine in the Brain: Recent Progress on Detection, Function, and Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhaofa WuState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing, 100871, China. Electronic address: wuzhaofa@pku.edu.cn.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing, 100871, China; Peking-Tsinghua Center for Life Sciences, Beijing, 100871, China; Chinese Institute for Brain Research, Beijing, 100871, China. Electronic address: yulongli@pku.edu.cn.

Funding

Novel fluorescent sensors based on GPCRs for imaging neuromodulationU01NS103558 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2017 to 2019
$2.2M
NINDS NIH HHS U01 NS103558
6 · The paper itself

Abstract

Purinergic transmitters such as adenosine, ADP, ATP, UTP, and UDP-glucose play important roles in a wide range of physiological processes, including the sleep-wake cycle, learning and memory, cardiovascular function, and the immune response. Moreover, impaired purinergic signaling has been implicated in various pathological conditions such as pain, migraine, epilepsy, and drug addiction. Examining the function of purinergic transmission in both health and disease requires direct, sensitive, non-invasive tools for monitoring structurally similar purinergic transmitters; ideally, these tools should have high spatial and temporal resolution in in vivo applications. Here, we review the recent progress with respect to the development and application of new methods for detecting purinergic transmitters, focusing on optical tools; in addition, we provide discussion regarding future perspectives.

Indexed as

AnimalsHumansNeurotransmitter AgentsOptical ImagingPurinergic AgentsReceptors, PurinergicNeurotransmitter AgentsPurinergic AgentsReceptors, PurinergicAdenosineATPImagingPurinergic transmittersSensors

Identifiers

PMID31958495
PMCPMC9188655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.