Evidence map›Paper›PMID 31958482›Full record

ArticleNeurochemistry international2020

Preclinical testing of the ketogenic diet in fragile X mice.

Pamela R Westmark, Alejandra Gutierrez, Aaron K Gholston, Taralyn M Wilmer, Cara J Westmark

Open access · greenAbstract read
In one paragraph

Article in Neurochemistry international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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  13. Diet in treatment of autism spectrum disorders.Frontiers in neuroscience · 2022
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pamela R WestmarkDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA.
Alejandra GutierrezDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA; Molecular Environmental Toxicology Center, Summer Research Opportunities Program, University of Wisconsin, Madison, WI, USA.
Aaron K GholstonDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA; Molecular Environmental Toxicology Center, Summer Research Opportunities Program, University of Wisconsin, Madison, WI, USA.
Taralyn M WilmerDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA.
Cara J WestmarkDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: westmark@wisc.edu.
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Summer Research Experience for Minority UndergraduatesR25ES020720 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD, Sean M. Ronnekleiv-Kelly · 2011 to 2026
$1.3M
NCATS NIH HHS UL1 TR002373NIEHS NIH HHS R25 ES020720
6 · The paper itself

Abstract

The ketogenic diet is highly effective at attenuating seizures in refractory epilepsy, and accumulating evidence in the literature suggests that it may be beneficial in autism. To our knowledge, no one has studied the ketogenic diet in any fragile X syndrome (FXS) model. FXS is the leading known genetic cause of autism. Herein, we tested the effects of chronic ketogenic diet treatment on seizures, body weight, ketone and glucose levels, diurnal activity levels, learning and memory, and anxiety behaviors in Fmr1

Indexed as

Diet, KetogenicAnimalsAnxietyDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeMemoryMice, KnockoutFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1ActigraphyAutismFragile X syndromeKetogenic dietSeizures

Identifiers

PMID31958482
PMCPMC7020810
OpenAlexW3000236061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.