Evidence map›Paper›PMID 31958451›Full record

ArticleJournal of immunological methods2020

Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations.

Colin Havenar-Daughton, Isabel G Newton, Somaye Y Zare, Samantha M Reiss, Brittany Schwan, Min Ji Suh, Farnaz Hasteh, Gina Levi, Shane Crotty

Open access · greenAbstract read
In one paragraph

Article in Journal of immunological methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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  18. Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Colin Havenar-DaughtonDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: chavenar@lji.org.
Isabel G NewtonDepartment of Radiology, Division of Interventional Radiology, University of California, San Diego, CA 92093, USA.; Veterans Administration San Diego Healthcare System, San Diego, CA 92161, USA.
Somaye Y ZareDepartment of Pathology, University of California San Diego, San Diego, CA 92103, USA.
Samantha M ReissDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.
Brittany SchwanClinical Studies Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Min Ji SuhDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Farnaz HastehDepartment of Pathology, University of California San Diego, San Diego, CA 92103, USA.
Gina LeviClinical Studies Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Shane CrottyDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA.. Electronic address: shane@lji.org.
La Jolla Institute for Immunology · USScripps Research Institute · USUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MCELRATH, MARGARET JULIANA · 2012 to 2018
$131.5M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Shane P Crotty · 2019 to 2026
$32.8M
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCATS NIH HHS UL1 TR001442NCRR NIH HHS S10 RR027366NIAID NIH HHS U19 AI142742NIAID NIH HHS UM1 AI100663NIAID NIH HHS UM1 AI144462
6 · The paper itself

Abstract

Germinal centers (GC) are critically important for maturation of the antibody response and generation of memory B cells, processes that form the basis for long-term protection from pathogens. GCs only occur in lymphoid tissue, such as lymph nodes, and are not present in blood. Therefore, GC B cells and GC T follicular helper (T

Indexed as

AdultBiopsy, Fine-NeedleB-LymphocytesCell SeparationFemaleGerminal CenterHumansImmunologic MemoryLymph NodesLymphocyte SubsetsMaleMiddle AgedT-Lymphocytes, Helper-InducerYoung Adult

Identifiers

PMID31958451
PMCPMC7200018
OpenAlexW2999592560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.