Observational studyChest2020
Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort.
Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Predictors of Acute Exacerbations in COPD: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review.Nutrition reviews · 2022Pooled it
- Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial.The American journal of clinical nutrition · 2022Trial
- Serum Vitamin D Levels, Systemic Inflammation, and Exacerbation Among Patients with COPD GOLD Group E.Biomedicines · 2026Article
- Impact of Severe Vitamin D Deficiency on Antibiotic Use in Hospitalized COPD Patients with Exacerbations: A Retrospective Analysis.International journal of chronic obstructive pulmonary disease · 2026Article
- Lower Vitamin D During Acute Exacerbation Is Associated with Very Severe Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2025Observational
- Nonlinear association between serum 25-hydroxyvitamin D concentrations and lung function in the United States adult population with COPD.Scientific reports · 2025Article
- Associations of Muscle-Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Role and Clinical Significance of Vitamin D in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Review
- Chronic obstructive pulmonary disease: in-depth analysis of microbiota association and innovative prevention and treatment approaches from the gut-lung axis perspective.Frontiers in immunology · 2025Review
- Nonlinear correlation and mediation effects between serum 25-hydroxyvitamin D levels and all-cause mortality in COPD patients.Frontiers in nutrition · 2024Article
- Association of Severe Vitamin D Deficiency with Hospitalization in the Previous Year in Hospitalized Exacerbated COPD Patients.International journal of chronic obstructive pulmonary disease · 2024Observational
- Vitamin D status in patients with chronic obstructive pulmonary disease at Chris Hani Baragwanath Hospital, Johannesburg, South Africa.African journal of thoracic and critical care medicine · 2024Article
- Vitamin D supplementation may be beneficial in improving the prognosis of patients with chronic obstructive pulmonary disease in the intensive care unit: a retrospective study.Frontiers in medicine · 2024Article
- Vitamin D Status and Longitudinal Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease - A Prospective Observational Study.International journal of chronic obstructive pulmonary disease · 2024Observational
- Gender Differences in Vitamin D Status and Determinants of Vitamin D Insufficiency in Patients with Chronic Obstructive Pulmonary Disease.Nutrients · 2023Observational
- Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2023Review
- The correlation between a Th1/Th2 cytokines imbalance and vitamin D level in patients with early chronic obstructive pulmonary disease (COPD), based on screening results.Frontiers in physiology · 2023Article
- Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?Journal of personalized medicine · 2022Article
- Perspectives: on Precision Nutrition Research in Heart, Lung, and Blood Diseases and Sleep Disorders.Advances in nutrition (Bethesda, Md.) · 2022Article
Corrections and comments
- Commented on by
Authors and funding
21 authors at 13 institutions in 1 country.
Robert M BurkesDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address: robert.burkes@unchealth.unc.edu.
Agathe S CeppeMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Claire M DoerschukDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
David CouperUniversity of North Carolina Gillings School of Global Public Health, Chapel Hill, NC.
Eric A HoffmanDepartment of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA.
Alejandro P ComellasDivision of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Carver College of Medicine, Iowa City, IA.
R Graham BarrDepartment of Epidemiology, Columbia University, New York, NY.
Jerry A KrishnanDivision of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Illinois at Chicago, Chicago, IL.
Christopher CooperDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.
Victor E OrtegaSection of Pulmonary, Critical Care, Allergy, and Immunologic Disease, Wake Forest University, Winston-Salem, NC.
J Michael WellsDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.
Gerard J CrinerDivision of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA.
Prescott G WoodruffDivision of Pulmonary Critical Care, Allergy, and Sleep Medicine, University of California, San Francisco, San Francisco, CA.
Russell P BowlerDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO.
Cheryl S PirozziDivision of Pulmonary and Critical Care Medicine, University of Utah, Salt Lake City, UT.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Robert A WiseDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Todd T BrownDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, MD.
M Bradley DrummondDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
SPIROMICS Investigators
University of North Carolina at Chapel Hill · USJohns Hopkins University · USUniversity of Iowa · USColumbia University · USNational Jewish Health · USTemple University · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of Utah · USWake Forest University · USUniversity of Michigan · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MPULMONARY CELLULAR AND MOLECULAR BIOLOGY TRAININGT32HL007749 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson · 1993 to 2026
$19.9MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MSputum Microbial Markers of Type 2-Low AsthmaR01AI129958 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, YVONNE JEAN · 2017 to 2021
$3.6MCathelicidin and Vitamin D: Impact on Populations At-Risk and with COPDR01HL125432 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DRUMMOND, MICHAEL BRADLEY · 2015 to 2019
$3.1MUltra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MThe Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744kClinical Significance of the Antimicrobial Peptide Cathelicidin in Acute Exacerbations of COPDF32HL143867 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURKES, ROBERT M · 2018 to 2019
$142kNHLBI NIH HHS F32 HL143867NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K08 HL123940NHLBI NIH HHS K24 HL137013NHLBI NIH HHS R01 HL125432NHLBI NIH HHS T32 HL007749NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIAID NIH HHS R01 AI129958NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIH HHS S10 OD018526
Abstract
backgroundThe relationship between 25-hydroxyvitamin D (25-OH-vitamin D) and COPD outcomes remains unclear. Using the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), we determined associations among baseline 25-OH-vitamin D and cross-sectional and longitudinal lung function and COPD exacerbations.
methodsSerum 25-OH-vitamin D level was measured in stored samples from 1,609 SPIROMICS participants with COPD. 25-OH-vitamin D levels were modeled continuously and dichotomized as deficient (< 20 ng/mL) vs not deficient (≥ 20 ng/mL). Outcomes of interest included % predicted FEV
resultsVitamin D deficiency was present in 21% of the cohort and was more prevalent in the younger, active smokers, and blacks. Vitamin D deficiency was independently associated with lower % predicted FEV
conclusionsVitamin D deficiency is associated with worse cross-sectional and longitudinal lung function and increased odds of prior COPD exacerbations. These findings identify 25-OH-vitamin D levels as a potentially useful marker of adverse COPD-related outcomes.
Indexed as
Pulmonary Disease, Chronic ObstructiveRespiratory Function TestsVitamin D DeficiencyBiomarkersCorrelation of DataDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedOutcome Assessment, Health CarePrevalenceSymptom Flare UpUnited StatesVitamin D25-hydroxyvitamin DBiomarkersVitamin DCOPDCOPD epidemiologyCOPD exacerbationslung functionvitamin D
Identifiers
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Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.