Trial reportRMD open2020
The impact of upper limb exercise on function, daily activities and quality of life in systemic lupus erythematosus: a pilot randomised controlled trial.
Trial report in RMD open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03802578 (The Impact of Exercise on Hand Function, on Activities of Daily Living), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Exercise on Hand Function, on Activities of Daily Living (ADLs) Performance and Quality of Life of Patients With Systemic Lupus Erythematosus (SLE)
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effects of exercise interventions on core health outcomes in patients with SLE: systematic review and meta-analysis.Lupus science & medicine · 2026Pooled it
- Efficacy of lifestyle interventions in the management of systemic lupus erythematosus: a systematic review of the literature.Rheumatology international · 2024Pooled it
- Pooled it
- Pooled it
- Pooled it
- Exercise as adjunctive therapy for systemic lupus erythematosus.The Cochrane database of systematic reviews · 2023Pooled it
- Effects of active action observation on cognitive, emotional, motor, and somatosensory outcomes in adolescents with juvenile idiopathic arthritis: a prospective exploratory case series.Frontiers in human neuroscience · 2026Article
- Clinical and Psychosocial Predictors of Physical Activity in Systemic Lupus Erythematosus: A Multicentre Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- The Effects of Exercise Training on Functional Aerobic Capacity and Quality of Life in Patients with Systemic Lupus Erythematosus: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2025Review
- EXamining the feasibility of exerCisE to manage symptoms of Lupus (EXCEL): a protocol for a randomised controlled pilot study.Lupus science & medicine · 2025Article
- Investigation of the effects of combined exercises and self-management education, with and without functional exercises, on pain and functional outcomes in patients with avascular necrosis of the femoral head: a protocol for a single-blind, randomised controlled trial with a parallel design and a 4 month follow-up.BMJ open sport & exercise medicine · 2025Article
- Rehabilitation in Systemic Lupus Erythematosus With Class 4 Lupus Nephritis Secondary to Pneumonia: A Case Report.Cureus · 2023Article
- Development and validation of the systemic lupus erythematous scale amongst the system of quality of life instruments for chronic diseases QLICD-SLE (V2.0).Health and quality of life outcomes · 2023Article
- Human skeletal muscle-specific atrophy with aging: a comprehensive review.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Article
- An examination of relationships between vitamin B12 status and functional measures of peripheral neuropathy in young adult vegetarians.Frontiers in nutrition · 2023Article
- Psychological Implications to the Therapy of Systemic Lupus Erythematosus.International journal of environmental research and public health · 2022Review
- Effects of Exercise Intervention on Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis of Controlled Trials.Healthcare (Basel, Switzerland) · 2021Review
- Patient-Reported Outcomes for Quality of Life in SLE: Essential in Clinical Trials and Ready for Routine Care.Journal of clinical medicine · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effect of upper limb exercise on hand function, daily activities performance and quality of life of patients with systemic lupus erythematosus (SLE).
methodsWe performed a pilot randomised, 24-week follow-up, unmasked controlled trial. Inclusion criteria were upper limb arthralgias, a Disabilities of Arm, Shoulder and Hand (DASH) questionnaire score >10 and a stable treatment over the past 3 months. Patients were randomly allocated in the routine care (control) or exercise group that received an individually tailored 30-min daily upper-limb exercise programme by a hand therapist for 12 weeks. We evaluated at 0, 6, 12 and 24 weeks the performance of daily activities for both groups with DASH questionnaire and Health Assessment Questionnaire (HAQ), the grip and pinch strength with Jamar dynamometer and pinch gauge tool, respectively, the dexterity with Purdue pegboard test, the quality of life with Lupus Quality of Life (LupusQoL) Questionnaire and the pain level by Visual Analogue Scale (VAS) score.
resultsFrom 293 consecutive SLE patients, data from 32 patients allocated to the exercise group and 30 to the control group were analysed. There was a significant difference between the two groups in percentage changes of DASH, HAQ, grip strength, pinch strength, LupusQoL-physical health and fatigue, and VAS scores from baseline to 6, 12 and 24 weeks, and from baseline to 12 weeks for dexterity test (p<0.001). No interaction was observed between exercise and disease activity or medication use at baseline and during the observation period.
conclusionUpper-limb exercise significantly improves hand function, pain, daily activity performance and quality of life in SLE. TRIAL REGISTRATION NUMBER: NCT03802578.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.