Evidence map›Paper›PMID 31958284›Full record

ArticleRMD open2020

Applying the 2019 EULAR/ACR lupus criteria to patients from an established cohort: a Latin American perspective.

Guillermo J Pons-Estel, Manuel Francisco Ugarte-Gil, Guillermina B Harvey, Daniel Wojdyla, Rosana Quintana, Verónica Saurit, Enrique R Soriano, Eloisa Bonfa, Loreto Massardo, Mario Cardiel and 5 more

Abstract readMulticenter Study
In one paragraph

Article in RMD open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Systemic lupus erythematosus as a genetic disease.Clinical immunology (Orlando, Fla.) · 2022
    Article
  5. A glimpse into the future of systemic lupus erythematosus.Therapeutic advances in musculoskeletal disease · 2022
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Guillermo J Pons-Estel *Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Santa Fe, Argentina gponsestel@hotmail.com.ORCID 0000-0002-0647-929X
Manuel Francisco Ugarte-Gil *School of Medicine, Universidad Cientifica del Sur, Lima, Peru.ORCID 0000-0003-1728-1999
Guillermina B HarveyEscuela de Estadística, Facultad de Ciencias Económicas y Estadística, Universidad Nacional de Rosario, Rosario, Argentina.
Daniel WojdylaEscuela de Estadística, Facultad de Ciencias Económicas y Estadística, Universidad Nacional de Rosario, Rosario, Argentina.
Rosana QuintanaCentro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Santa Fe, Argentina.
Verónica SauritServicio de Reumatología, Hospital Privado Universitario de Córdoba, Córdoba, Córdoba, Argentina.
Enrique R SorianoRheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Eloisa BonfaRheumatology, Faculdade de Medicina da Universidade de São Paulo-USP, São Paulo, SP, Brazil.
Loreto MassardoCentro de Biología Celular y Biomedicina, Universidad San Sebastián, Santiago, Chile.
Mario CardielCentro de Investigacion Clinica de Morelia, Morelia, Michoacán, Mexico.
Luis M VilaDivision of Rheumatology, University of Puerto Rico, San Juan, San Juan, Puerto Rico.
Russell GriffinEpidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bernardo A Pons-EstelCentro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Santa Fe, Argentina.
Graciela S AlarcónDepartment of Medicine, Division of Clinical Immunology and Rheumatology, School of Medicine, The University of Alabama, Birmingham, Alabama, USA.
Grupo Latino Americano De Estudio de Lupus (GLADEL)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the performance of the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) criteria in terms of earlier patients' classification in comparison to the 1982/1997 ACR or the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria. MATERIALS AND

methodsPatients from a Latin America, multiethnic, multicentre cohort, where SLE was defined using the physicians' diagnosis, were included. To calculate the sensitivity of the 2019 EULAR/ACR criteria, the 1982/1997 ACR criteria were considered the gold standard. Additionally, comparison of the 1982/1997 ACR criteria and the 2012 SLICC criteria with the 2019 EULAR/ACR criteria was performed.

resultsThe sensitivity of the 2019 EULAR/ACR criteria when compared with the 1982/1997 ACR criteria as the gold standard was 91.3%. This new set of criteria allowed an earlier SLE patient classification in 7.4% (mean 0.67 years) and 0.6% (mean 1.47 years) than the 1982/1997 ACR and the 2012 SLICC criteria, respectively. Patients accruing the 2019 EULAR/ACR earlier than the 1982/1997 ACR criteria were more likely to have high anti-dsDNA titres; those accruing them later were less likely to have mucocutaneous and joint manifestations; this was not observed when comparing them with the 2012 SLICC criteria.

conclusionsThe 2019 EULAR/ACR criteria classified earlier only a small proportion of Latin America patients than with the two other criteria sets in real-life clinical practice scenarios. Further studies in different patient populations are needed before these new criteria are adopted worldwide.

Indexed as

Societies, MedicalAdolescentAdultEuropeFemaleHumansLatin AmericaLupus Erythematosus, SystemicMaleRheumatologySensitivity and SpecificitySeverity of Illness IndexUnited StatesYoung Adultautoimmune diseasesepidemiologysystemic lupus erythematosus

Identifiers

PMID31958284
PMCPMC6999682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.