Evidence map›Paper›PMID 31958270›Full record

ArticleeLife2020

Alexander Karge, Nicolle A Bonar, Scott Wood, Christian P Petersen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. An insight into planarian regeneration.Cell proliferation · 2022
    Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexander KargeDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0003-2439-326X
Nicolle A BonarDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Scott WoodDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.
Christian P PetersenDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0001-7552-6865
Northwestern University · US

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Enhancement of neural regenerationR01GM130835 · NIGMS · NORTHWESTERN UNIVERSITY · PI PETERSEN, CHRISTIAN · 2019 to 2022
$1.7M
Cell signaling in regeneration and tissue scalingR01GM129339 · NIGMS · NORTHWESTERN UNIVERSITY · PI PETERSEN, CHRISTIAN · 2019 to 2022
$1.2M
Natural Sciences and Engineering Research Council of Canada PGSD3-471547-2015NIGMS NIH HHS R01 GM129339NIGMS NIH HHS R01 GM130835NIGMS NIH HHS T32 GM008061NIH HHS 1R01GM129339
6 · The paper itself

Abstract

Negative regulators of adult neurogenesis are of particular interest as targets to enhance neuronal repair, but few have yet been identified. Planarians can regenerate their entire CNS using pluripotent adult stem cells, and this process is robustly regulated to ensure that new neurons are produced in proper abundance. Using a high-throughput pipeline to quantify brain chemosensory neurons, we identify the conserved tyrosine kinase

Indexed as

PlanariansProtein-Tyrosine KinasesAnimalsBrainBrain ChemistryNeurogenesisNeuronsRegenerationRNA InterferenceProtein-Tyrosine KinasesTec protein-tyrosine kinasecell deathdevelopmental biologyneurogenesisprotein kinaseregenerationsignalingS. mediterranea

Identifiers

PMID31958270
PMCPMC6970515
OpenAlexW3002028658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.