ArticleeLife2020
Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Aversive 22-kHz ultrasonic vocalization playback reveals differences in affective (dys)function following early life adversity in male and female juvenile rats.Behavioural brain research · 2026Article
- Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood.bioRxiv : the preprint server for biology · 2026Article
- Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles.Neurobiology of stress · 2026Article
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Transient synaptic refinement and glial adaptations after whisker denervation in adult mice.Frontiers in cellular neuroscience · 2026Article
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neurobiology of resilience to early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Generative models of living development: an interaction-centered proposal and its implications for artificial life research.Frontiers in systems biology · 2026Review
- Article
- Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.Neurobiology of stress · 2025Article
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood.Neurobiology of learning and memory · 2025Article
- Effects of Early Stress Exposure on Anxiety-like Behavior andBiomolecules · 2024Article
- Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression.Science advances · 2024Article
- The relationship between childhood trauma and mental health status among Chinese vocational high school adolescents: the mediating effect of poor self-control and internet addiction.BMC public health · 2024Article
- Article
- Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders.Molecular psychiatry · 2024Review
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Authors and funding
9 authors.
Funding
Abstract
Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have been identified with a clear need for individualized intervention strategies, the neurobiological substrates of ELA-attributable differences remain unknown due to a paucity of translational investigations taking both development and sex into account. Male and female rats exposed to maternal separation ELA were analyzed with anterograde tracing from basolateral amygdala (BLA) to PFC to identify sex-specific innervation trajectories through juvenility (PD28) and adolescence (PD38;PD48). Resting-state functional connectivity (rsFC) was assessed longitudinally (PD28;PD48) in a separate cohort. All measures were related to anxiety-like behavior. ELA-exposed rats showed precocial maturation of BLA-PFC innervation, with females affected earlier than males. ELA also disrupted maturation of female rsFC, with enduring relationships between rsFC and anxiety-like behavior. This study is the first providing both anatomical and functional evidence for sex- and experience-dependent corticolimbic development.
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