Evidence map›Paper›PMID 31958036›Full record

ArticleAutophagy2020

IFNB/interferon-β regulates autophagy via a

Patrick Ejlerskov, David C Rubinsztein, Roger Pocock

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Patrick EjlerskovBiotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
David C RubinszteinCambridge Institute for Medical Research (CIMR, University of Cambridge, Cambridge, UK.
Roger PocockDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.ORCID 0000-0002-5515-3608
Monash University · AUUniversity of Cambridge · GBUniversity of Copenhagen · DK

Funding

Medical Research Council UKDRI-2002Wellcome TrustWellcome Trust 095317/Z/11/Z
6 · The paper itself

Abstract

Loss of IFNB/interferon-β in mice causes a Parkinson disease-like phenotype where many features, including SNCA/α-synuclein and MAPT/tau accumulation, can be attributed to a late-stage block in autophagic flux. Recently, we identified a mechanism that can explain this phenotype. We found that IFNB induces expression of

Indexed as

AnimalsAutophagyGTPase-Activating ProteinsHumansInterferon-betaMicroRNAsrab GTP-Binding ProteinsGTPase-Activating ProteinsInterferon-betaMicroRNAsMIRN1 microRNA, humanrab GTP-Binding ProteinsTBC1D15 protein, humanAutophagyHuntington diseaseinterferon-betamiR-1Parkinson diseaseproteinopathiesTBC1D15

Identifiers

PMID31958036
PMCPMC7138209
OpenAlexW3003080326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.