ArticleJournal of experimental botany2020
Calcium channel CNGC19 mediates basal defense signaling to regulate colonization by Piriformospora indica in Arabidopsis roots.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 63 citations in OpenAlex.
- Arabidopsis thaliana Cyclic Nucleotide-Gated Channel 19 is involved in root extracellular ATP and Pep1 signalling.The New phytologist · 2025Article
- Article
- Microbial-mediated induced resistance: interactive effects for improving crop health.Frontiers in microbiology · 2025Review
- The cyclic nucleotide-gated channels CNGC2 and CNGC4 support systemic wound responses inFrontiers in plant science · 2025Article
- Genome-wide identification of cyclic nucleotide-gated channel gene family inFrontiers in plant science · 2025Article
- The Influence ofPlants (Basel, Switzerland) · 2024Article
- Genome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum.BMC genomics · 2023Article
- Optimal culture conditions ofPlant biotechnology (Tokyo, Japan) · 2023Article
- Callose metabolism and the regulation of cell walls and plasmodesmata during plant mutualistic and pathogenic interactions.Plant, cell & environment · 2023Review
- Integration of Electrical Signals and Phytohormones in the Control of Systemic Response.International journal of molecular sciences · 2023Review
- A histochemical reporter system to study extracellular ATP response in plants.Frontiers in plant science · 2023Article
- Transcriptome analysis reveals the regulation of cyclic nucleotide-gated ion channels in response to exogenous abscisic acid and calcium treatment under drought stress in tomato.Frontiers in genetics · 2023Article
- Molecular mechanisms ofPlant signaling & behavior · 2022Article
- The calcium sensor CBL7 is required for Serendipita indica-induced growth stimulation in Arabidopsis thaliana, controlling defense against the endophyte and KPlant, cell & environment · 2022Article
- CaThe EMBO journal · 2022Review
- Con-CaThe New phytologist · 2022Review
- A tale of many families: calcium channels in plant immunity.The Plant cell · 2022Review
- Piriformospora indica recruits host-derived putrescine for growth promotion in plants.Plant physiology · 2022Article
- Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity.The Plant journal : for cell and molecular biology · 2022Article
- Induced Systemic Resistance for Improving Plant Immunity by Beneficial Microbes.Plants (Basel, Switzerland) · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activation of calcium signaling is a crucial event for perceiving environmental stress. Colonization by Piriformospora indica, a growth-promoting root endosymbiont, activates cytosolic Ca2+ in Arabidopsis roots. In this study, we examined the role and functional relevance of calcium channels responsible for Ca2+ fluxes. Expression profiling revealed that CYCLIC NUCLEOTIDE GATED CHANNEL 19 (CNGC19) is an early-activated gene, induced by unidentified components in P. indica cell-wall extract. Functional analysis showed that loss-of-function of CNGC19 resulted in growth inhibition by P.indica, due to increased colonization and loss of controlled fungal growth. The cngc19 mutant showed reduced elevation of cytosolic Ca2+ in response to P. indica cell-wall extract in comparison to the wild-type. Microbe-associated molecular pattern-triggered immunity was compromised in the cngc19 lines, as evidenced by unaltered callose deposition, reduced cis-(+)-12-oxo-phytodienoic acid, jasmonate, and jasmonoyl isoleucine levels, and down-regulation of jasmonate and other defense-related genes, which contributed to a shift towards a pathogenic response. Loss-of-function of CNGC19 resulted in an inability to modulate indole glucosinolate content during P. indica colonization. CNGC19-mediated basal immunity was dependent on the AtPep receptor, PEPR. CNGC19 was also crucial for P. indica-mediated suppression of AtPep-induced immunity. Our results thus demonstrate that Arabidopsis CNGC19 is an important Ca2+ channel that maintains a robust innate immunity and is crucial for growth-promotion signaling upon colonization by P. indica.
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