Trial reportHypertension (Dallas, Tex. : 1979)2020
Effects of Sodium Reduction on Energy, Metabolism, Weight, Thirst, and Urine Volume: Results From the DASH (Dietary Approaches to Stop Hypertension)-Sodium Trial.
Trial report in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Acute sodium bicarbonate supplementation reduces the increase in markers of acute kidney injury during physical work in the heat.European journal of applied physiology · 2025Trial
- Sex and race differences in urinary Tumor Necrosis Factor-α (TNF-α) levels: Secondary analysis of the DASH-sodium trial.Journal of human hypertension · 2023Trial
- High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults.American journal of physiology. Renal physiology · 2022Trial
- Urine Metabolites Associated with the Dietary Approaches to Stop Hypertension (DASH) Diet: Results from the DASH-Sodium Trial.Molecular nutrition & food research · 2021Trial
- Maternal Diet, Lifestyle Factors, and Gestational Weight Gain: A Single-Center Case-Control Study in Hungary.Nutrients · 2026Article
- Effect of High-Salt Diet on Memory and Behavior in Mice Expressing Human Apolipoprotein Epsilon-4 (APOE4) Allele.NeuroSci · 2026Article
- Association Between Increased Dietary Sodium Intake and Higher Water Intake from Fluid and Food in Children.Nutrients · 2025Article
- Dietary Sodium Reduction Is Best for Reducing Blood Pressure: Controversies in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024Article
- A Clustering Study of Dietary Patterns and Physical Activity among Workers of the Uruguayan State Electrical Company.Nutrients · 2024Article
- Peer (dyadic) support: a hypertension feasibility study for older African American women.AIMS public health · 2024Article
- Less sodium, more potassium, or both: population-wide strategies to prevent hypertension.American journal of physiology. Renal physiology · 2023Review
- Review
- Home-delivered meals as an adjuvant to improve volume overload and clinical outcomes in hemodialysis.Clinical kidney journal · 2022Article
- Serum aldosterone and urine electrolytes dynamics in response to DASH diet intervention - An inpatient mechanistic study.Journal of clinical and translational science · 2022Article
- Arterial hypertension - Clinical trials update 2021.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Review
- High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension.Cardiovascular research · 2021Article
- Association of Usual Sodium Intake with Obesity Among US Children and Adolescents, NHANES 2009-2016.Obesity (Silver Spring, Md.) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Two recent studies challenged traditional paradigms of mammalian sodium physiology, suggesting that sodium reduction might cause weight gain by altering metabolism. This new theory has important implications for population-wide dietary recommendations. However, these observations have not been confirmed. In the DASH (Dietary Approaches to Stop Hypertension)-Sodium trial, 412 adults with systolic blood pressure of 120 to 159 mm Hg and diastolic blood pressure of 80 to 95 mm Hg not taking antihypertensive medications were randomly assigned to the DASH diet or a control diet (parallel design). On their assigned diet, participants randomly consumed each of the 3 sodium levels for 4 weeks (crossover design). Participants were provided all meals but could drink noncaloric beverages (eg, water) freely. Throughout the trial, energy intake was adjusted to maintain weight constant. The 3 sodium levels (at 2100 kcal/day) were: low (1150 mg of Na/day), medium (2300 mg of Na/day), and high (3450 mg of Na/day). Energy intake, weight, self-reported thirst, and 24-hour urine volume were assessed after each period. Participants were 57% women and 57% black; mean age was 48 years [SD, 10]). Among those assigned the control, mean weight increased slightly with higher sodium but not among those assigned DASH. Energy intake did not vary across sodium levels in either diet (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.