Evidence map›Paper›PMID 31957003›Full record

ReviewClinical pharmacology and therapeutics2020

Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology?

Alex Zhavoronkov, Quentin Vanhaelen, Tudor I Oprea

Abstract readReview
In one paragraph

Review in Clinical pharmacology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
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  11. Progress, Pitfalls, and Impact of AI-Driven Clinical Trials.Clinical pharmacology and therapeutics · 2025
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alex ZhavoronkovPharmaceutical Artificial Intelligence Department, Insilico Medicine, Hong Kong, Hong Kong.ORCID 0000-0001-7067-8966
Quentin VanhaelenPharmaceutical Artificial Intelligence Department, Insilico Medicine, Hong Kong, Hong Kong.ORCID 0000-0002-4611-2046
Tudor I OpreaDepartment of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.ORCID 0000-0002-6195-6976

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Machine Learning Model Validation for AD/ADRDU24CA224370 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI EDWARDS, JEREMY S · 2018 to 2023
$6.4M
Resource Dissemination and Outreach Center for Illuminating the Druggable GenomeU24TR002278 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SCHURER, STEPHAN C, SKLAR, LARRY A. · 2018 to 2023
$3.7M
Illuminating the Druggable Genome by Knowledge GraphsU01CA239108 · NCI · JACKSON LABORATORY · PI MUNGALL, CHRISTOPHER J, OPREA, TUDOR I · 2019 to 2021
$1.7M
NCATS NIH HHS U24 TR002278NCI NIH HHS P30 CA118100NCI NIH HHS U01 CA239108NCI NIH HHS U24 CA224370NIH HHS P30 CA118100NIH HHS U01 CA239108NIH HHS U24 CA224370NIH HHS U24 TR002278
6 · The paper itself

Abstract

As the field of artificial intelligence and machine learning (AI/ML) for drug discovery is rapidly advancing, we address the question "What is the impact of recent AI/ML trends in the area of Clinical Pharmacology?" We address difficulties and AI/ML developments for target identification, their use in generative chemistry for small molecule drug discovery, and the potential role of AI/ML in clinical trial outcome evaluation. We briefly discuss current trends in the use of AI/ML in health care and the impact of AI/ML context of the daily practice of clinical pharmacologists.

Indexed as

AnimalsArtificial IntelligenceClinical Trials as TopicDrug DiscoveryHumansPharmacology, Clinical

Identifiers

PMID31957003
PMCPMC7158211

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.