SynthesisHeart failure reviews2020
Malignancy predicts outcome of Takotsubo syndrome: a systematic review and meta-analysis.
Synthesis in Heart failure reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Malignancy predicts short-term mortality in Takotsubo: insights from a meta-analysis of 125 359 patients.ESC heart failure · 2021Pooled it
- Prognostic factors of Takotsubo cardiomyopathy: a systematic review.ESC heart failure · 2021Pooled it
- Association between neutrophil percentage to albumin ratio and mortality in takotsubo syndrome patients: analysis of the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Impact of sex on the outcome of troponin-positive patients with non-obstructive coronary arteries.Scientific reports · 2025Article
- Trigger-Associated Clinical Implications and Outcomes in Takotsubo Syndrome: Results From the Multicenter GEIST Registry.Journal of the American Heart Association · 2023Article
- Clinical outcomes of takotsubo syndrome in patients with cancer: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- A contemporary update on cancer and takotsubo syndrome.Frontiers in cardiovascular medicine · 2023Review
- Article
- Takotsubo Syndrome: Translational Implications and Pathomechanisms.International journal of molecular sciences · 2022Review
- Comparison of Outcomes in Patients With Takotsubo Syndrome With-vs-Without Cardiogenic Shock.The American journal of cardiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the recent years, studies have emerged reporting on a strong relationship between the occurrence of malignancy and Takotsubo syndrome. The aim of this systematic review and meta-analysis is to evaluate the predictive value of malignancy for prognosis of Takotsubo syndrome patients. PubMed, EMBASE, Cochrane Library, Web of science, and Scopus were searched until 4 September 2019 for articles concerning association of malignancy with the prognosis of Takotsubo syndrome. A total of ten studies were finally included in this meta-analysis, demonstrating that malignancy was associated with higher mortality in Takotsubo syndrome patients (RR 2.23, 95% CI 1.64-3.03, Z = 5.10, P < 0.00001). Differences between individual studies were significant, which were due to sample size and percentage of malignant patients in each study indicated by meta-regression and then verified by sensitivity analysis. Subgroup analysis demonstrated that the predictive value of malignancy in mortality risk of Takotsubo syndrome patients was significant for both in-hospital death (RR 2.26, 95% CI 1.34-3.82, Z = 3.06, P = 0.002) and follow-up death (RR 2.04, 95% CI 1.63-2.55, Z = 6.21, P < 0.00001). Further analysis of other in-hospital outcomes demonstrated increased incidence of mechanical ventilation in cancer patients. Our meta-analysis suggested that malignancy plays a significant role in predicting the mortality of Takotsubo syndrome patients whether in the short term or long term.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.