ArticleBioactive materials2020
From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading.
Article in Bioactive materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Increased Flexibility and Hemocompatibility of NO-Releasing Small Diameter Vascular Grafts in an Ex Vivo Sheep Model.ACS omega · 2026Article
- Biomimetic Functional Fluorinated Oxygen-Containing Coatings on 3D-Printing Composite Polymer Items.Polymers · 2025Article
- Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules.Exploration (Beijing, China) · 2025Article
- Bivalirudin functionalized hydrogel coating capable of catalytical NO-generation for enhanced anticorrosion and biocompatibility of magnesium alloy.Materials today. Bio · 2025Article
- Dual-Fuel Propelled Nanomotors with Two-Stage Permeation for Deep Bacterial Infection in the Treatment of Pulpitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Covalent coating strategy for enhancing the biocompatibility and hemocompatibility of blood-contacting medical materials.Pharmaceutical science advances · 2023Review
- Integration of Biofunctional Molecules into 3D-Printed Polymeric Micro-/Nanostructures.Polymers · 2022Article
- Advances in hydrogel-based vascularized tissues for tissue repair and drug screening.Bioactive materials · 2022Review
- Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection.Research (Washington, D.C.) · 2022Article
- Photoactivatable nanogenerators of reactive species for cancer therapy.Bioactive materials · 2021Review
- Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents.Bioactive materials · 2021Article
- Coaxial-printed small-diameter polyelectrolyte-based tubes with an electrostatic self-assembly of heparin and YIGSR peptide for antithrombogenicity and endothelialization.Bioactive materials · 2021Article
- Thermo-responsive imprinted hydrogel with switchable sialic acid recognition for selective cancer cell isolation from blood.Bioactive materials · 2021Article
- Combination strategies for antithrombotic biomaterials: an emerging trend towards hemocompatibility.Biomaterials science · 2021Article
- Photo-functionalized TiOBioactive materials · 2021Article
- Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Nanoparticles modified by polydopamine: Working as "drug" carriers.Bioactive materials · 2020Review
- Multipronged Approach to Combat Catheter-Associated Infections and Thrombosis by Combining Nitric Oxide and a Polyzwitterion: a 7 Day In Vivo Study in a Rabbit Model.ACS applied materials & interfaces · 2020Article
- Nitric Oxide-Producing Cardiovascular Stent Coatings for Prevention of Thrombosis and Restenosis.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications. However, the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring sites. Herein, we propose a novel concept of film engineering strategy "from surface to bulk synergetic modification". This new concept is realized by employing the surface amine groups of plasma polymerized allylamine (PPAm) film for grafting a molecule e.g., thrombin inhibitor, bivalirudin (BVLD), meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide (NO) gas as supplement to the functions of BVLD. It is demonstrated that such a "from surface to bulk synergetic modification" film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions, giving rise to a highly endothelium-mimetic thromboresistant property. We believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties, which will find broad biomedical applications in blood-contacting devices, and et al. Moreover, it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials.
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