ArticleInternational journal of ophthalmology2020
Different modes of foveal regeneration after closure of full-thickness macular holes by (re)vitrectomy and autologous platelet concentrate.
Article in International journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Role of autologous platelet-rich plasma for recurrent or refractory macular hole in the era of various flap techniques: a meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Pooled it
- Macular Pigment Optical Density Levels Reflect Retinal Remodeling in Lamellar Macular Holes.Investigative ophthalmology & visual science · 2026Observational
- Secondary macular hole following subretinal T-PA injection for subretinal hemorrhage: a case report.International journal of surgery case reports · 2026Article
- Platelet concentrates in macular hole surgery. A journey through the labyrinth of terminology, preparation, and application: a comprehensive review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Temporal inverted internal limiting membrane flap technique for myopic macular hole retinal detachment reconstruction.The Journal of international medical research · 2024Article
- Macular buckling alone versus combined inverted ILM flap on macular hole-associated macular detachment in patients with high myopia.Eye (London, England) · 2023Article
- Comparison of long-term visual and anatomical outcomes between internal limiting membrane flap and peeling techniques for macular holes with a propensity score analysis.Eye (London, England) · 2023Article
- Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group.International journal of retina and vitreous · 2023Article
- The effect comparison of ILM flap and traditional ILM peeling in iMH.Frontiers in medicine · 2023Article
- How internal limiting membrane peeling revolutionized macular surgery in the last three decades.International journal of ophthalmology · 2023Article
- Foveal reorganization after treatment of acute foveal toxoplasmic retinochoroiditis.Journal of ophthalmic inflammation and infection · 2021Article
- Degenerative lamellar macular holes: tractional development and morphological alterations.International ophthalmology · 2021Article
- The Role of Internal Limiting Membrane Flap for Highly Myopic Macular Hole Retinal Detachment: Improving the Closure Rate but Leading to Excessive Gliosis.Frontiers in medicine · 2021Article
- Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study.International ophthalmology · 2020Article
- Auto-transplantation of the anterior lens capsule and blood for a recurrent large macular hole.International journal of ophthalmology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana (re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome.
methodsA retrospective case series of 8 eyes of 8 patients was described.
resultsIn all cases investigated, the platelet-assisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure; the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea; a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial (RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer (ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.
conclusionThe data show that there are different modes of foveal regeneration after closure of macular holes with (re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells.
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Registered trials
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