ArticleQuantitative imaging in medicine and surgery2020
Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Mapping hippocampal-cerebellar functional connectivity across the human adult lifespan.Communications biology · 2025Article
- K-operator for Modelling Neurodegeneration: Simulations, fMRI Application, Eigenvalue Analysis and Recurrence Plots.Journal of medical systems · 2025Article
- Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome can Lead to Long-Term Neurological, Neuropsychological, and Cognitive Sequelae Associated with Cerebellar Atrophy.Cerebellum (London, England) · 2025Article
- Deep Learning Cerebellar Magnetic Resonance Imaging Segmentation in Late-Onset GM2 Gangliosidosis: Implications for Phenotype.medRxiv : the preprint server for health sciences · 2025Article
- Functional and structural cerebellar-behavior relationships in aging.Brain structure & function · 2024Article
- Territory-Related Functional Connectivity Changes Associated with Verbal Memory Decline in Patients with Unilateral Asymptomatic Internal Carotid Stenosis.AJNR. American journal of neuroradiology · 2024Article
- Altered resting-state cerebellar-cerebral functional connectivity in patients with end-stage renal disease.Renal failure · 2023Article
- The cerebellum is causally involved in episodic memory under aging.GeroScience · 2023Article
- Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory.NeuroImage · 2023Article
- Three-Dimensional Digital Reconstruction of the Cerebellar Cortex: Lobule Thickness, Surface Area Measurements, and Layer Architecture.Cerebellum (London, England) · 2023Article
- The language-related cerebro-cerebellar pathway in humans: a diffusion imaging-based tractographic study.Quantitative imaging in medicine and surgery · 2023Article
- Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.Neuroscience and biobehavioral reviews · 2022Review
- Development and evaluation of a T1 standard brain template for Alzheimer disease.Quantitative imaging in medicine and surgery · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human cerebellum plays an essential role in motor control, is involved in cognitive function and helps to regulate emotional responses. However, little is known about the relationship between cerebellar lobules and age-related memory decline. We aimed to investigate volume alterations in cerebellar lobules at different ages and assess their correlations with reduced memory recall abilities.
methodsA sample of 275 individuals were divided into the following four groups: 20-35 years (young), 36-50 years (early-middle age), 51-65 years (late-middle age), and 66-89 years (old). Volumes of the cerebellar lobules were obtained using volBrain software. Analysis of covariance and post hoc analysis were used to analyze group differences in cerebellar lobular volumes, and multiple comparisons were performed using the Bonferroni method. Spearman correlation was used to investigate the relationship between lobular volumes and memory recall scores.
resultsIn this study, we found that older adults had smaller cerebellar volumes than the other subjects. Volumetric decreases in size were noted in bilateral lobule VI and lobule crus I. Moreover, the volumes of bilateral lobule crus I, lobule VI, and right lobule IV were significantly associated with memory recall scores.
conclusionsIn the present study, we found that some lobules of the cerebellum appear more predisposed to age-related changes than other lobules. These findings provide further evidence that specific regions of the cerebellum could be used to assess the risk of memory decline across the adult lifespan.
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