ArticleQuantitative imaging in medicine and surgery2020
Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Physics-informed deep learning enables reliable and scalable organoid quantification for drug screening via OCT.NPJ digital medicine · 2026Article
- Virtual histology imaging of lymph nodesCancer biology & medicine · 2026Observational
- Longitudinal investigation of prostate tumor spheroid proliferation with dynamic line-field optical coherence tomography.Biomedical optics express · 2026Article
- Review of dynamic optical coherence tomography for intracellular motility: signals, metrics, and their applications [Invited].Biomedical optics express · 2025Review
- Quantitative evaluation of the site-dependent cell viability in three-dimensional hepatocyte spheroids based on dynamic optical coherence tomography.Journal of biomedical optics · 2025Article
- Longitudinal tracking of perfluorooctanoic acid exposure on mammary epithelial cell spheroids by dynamic optical coherence tomography.Biomedical optics express · 2024Article
- Compressed intracellular motility via non-uniform temporal sampling in dynamic optical coherence tomography.Journal of biomedical optics · 2024Article
- Dual-modality imaging system for monitoring human heart organoids beating in vitro.Optics letters · 2023Article
- Dynamic optical coherence tomography for cell analysis [Invited].Biomedical optics express · 2023Review
- Automated detection and growth tracking of 3D bio-printed organoid clusters using optical coherence tomography with deep convolutional neural networks.Frontiers in bioengineering and biotechnology · 2023Article
- Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride.Translational vision science & technology · 2022Article
- Imaging and characterization of transitions in biofilm morphology via anomalous diffusion following environmental perturbation.Biomedical optics express · 2022Article
- Segmentation of the urothelium in optical coherence tomography images with dynamic contrast.Journal of biomedical optics · 2021Article
- Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture.ACS biomaterials science & engineering · 2021Review
- Volumetric growth tracking of patient-derived cancer organoids using optical coherence tomography.Biomedical optics express · 2021Article
- Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response.Journal of biomedical optics · 2021Article
- Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues.Journal of biomedical optics · 2021Article
- Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis.Biomedical optics express · 2020Article
- Imaging intracellular motion with dynamic micro-optical coherence tomography.Biomedical optics express · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAn understanding of how the mammary gland responds to toxicant and drug exposures can shed light on mechanisms of breast cancer initiation/progression and therapeutic effectiveness, respectively. In this study, we employed noninvasive, label-free and high-throughput optical coherence tomography speckle fluctuation spectroscopy (OCT-SFS) to track exposure-response relationships in three-dimensional (3D) mammary epithelial organoid models.
methodsOCT-SFS is sensitive to relatively high speed (~0.16-8 µm/min) motions of subcellular light scattering components occurring over short (~2-114 s) time scales, termed "intracellular motility." In this study, OCT speckle fluctuation spectra are quantified by two metrics: the intracellular motility amplitude,
resultsIn this work, we observed a significant decrease in both
conclusionsOCT-SFS revealed cell line-specific response patterns, in terms of intracellular motility, to different motility suppression mechanisms. This provides a foundation for future OCT-SFS studies of longitudinal responses of the mammary gland in toxicology and drug research.
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