ArticlePhotoacoustics2020
Three-dimensional label-free imaging of mammalian yolk sac vascular remodeling with optical resolution photoacoustic microscopy.
Article in Photoacoustics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Loss of the maternal effect gene NLRP2 impairs embryonic and extra-embryonic development, revealing a novel genetic cause of congenital anomalies†.Biology of reproduction · 2026Article
- Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.Placenta · 2026Article
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- High speed innovations in photoacoustic microscopy.Npj imaging · 2024Review
- Functional Photoacoustic Imaging for Placental Monitoring: A Mini Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Review
- Modeling of Rapid Pam Systems Based on Electrothermal Micromirror for High-Resolution Facial Angiography.Sensors (Basel, Switzerland) · 2023Article
- Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: "Always-On" and "Turn-On" Probes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Noninvasive Dual-Modality Photoacoustic-Ultrasonic Imaging to Detect Mammalian Embryo Abnormalities after Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study.Environmental health perspectives · 2022Article
- Intravital Whole-Process Monitoring Thermo-Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long-Term Microscopic Precise Imaging Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Quickly Alternating Green and Red Laser Source for Real-time Multispectral Photoacoustic Microscopy.Photoacoustics · 2020Article
- Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Vessel development in the yolk sac is important for the embryo development and the malfunction of which can lead to cardiac dysfunction, embryonic malformation and miscarriage. Although substantial emphasis has been placed on the yolk sac vascular remodeling, no detailed three-dimensional (3D) imaging and quantitative analysis of this process has been described. Herein, we explored the development of the vascular system in the visceral yolk sac (VYS) on E11.5, E12.5 and E13.5 mouse embryos using a home-built large field-of-view (FOV) optical-resolution photoacoustic microscopy (OR-PAM). The results showed that OR-PAM can be used as a label-free imaging tool for studying the 2D/3D morphology changes of the vascular system during organogenesis. In addition, after a quantitative analysis the results showed that the microvascular density in the VYS gradually reduced along with the embryo growth. Vascular density in the VYS of E11.5 mouse embryos was almost 6-fold than that of E13.5. Hovever, the averaged vessel diameter of the entire VYS membrane increased gradually with the development of embryos. This study suggests that OR-PAM is a potential tool for acquiring the hemodynamic parameters of mammalian embryos, which could be further used for studying diseases related with the vascular remodeling such as vascular malformations and heart defects.
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Registered trials
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