Evidence map›Paper›PMID 31956421›Full record

ArticlePilot and feasibility studies2020

Dynamic LED light versus static LED light for depressed inpatients: results from a randomized feasibility trial.

Carlo Volf, Anne Sofie Aggestrup, Signe Dunker Svendsen, Torben Skov Hansen, Paul Michael Petersen, Carsten Dam-Hansen, Ulla Knorr, Ema Erkocevic Petersen, Janus Engstrøm, Ida Hageman and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03363529 (ROOM-LIGHT), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03363529 nacompletednot on this map

ROOM-LIGHT: Dynamic LED-light as Treatment for Depressed Patients in Inpatient Wards: A Feasibility Trial

TypeinterventionalSponsorUniversity Hospital Bispebjerg and FrederiksbergRan2017 to 2019Enrolled15ConditionsDepression, Light, Therapy, Complications, Sleep Disorders, Circadian RhythmArmsDynamic light, Standard
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Carlo VolfNID GROUP, Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Anne Sofie AggestrupNID GROUP, Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Signe Dunker SvendsenNID GROUP, Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Torben Skov HansenChromaviso A/S, Aarhus, Denmark.
Paul Michael Petersen3Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Carsten Dam-Hansen3Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
Ulla KnorrNID GROUP, Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Ema Erkocevic Petersen4Copenhagen Trial Unit, Centre for clinical intervention research, Rigshospitalet, Copenhagen, Denmark.
Janus Engstrøm4Copenhagen Trial Unit, Centre for clinical intervention research, Rigshospitalet, Copenhagen, Denmark.
Ida Hageman5Mental Health Services, Capital Region, Copenhagen, Denmark.
Janus Christian Jakobsen4Copenhagen Trial Unit, Centre for clinical intervention research, Rigshospitalet, Copenhagen, Denmark.
Klaus MartinyNID GROUP, Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-7317-5958
University of Copenhagen · DKCopenhagen University Hospital · DKTechnical University of Denmark · DKMental Health Services · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetrospective studies conducted in psychiatric wards have indicated a shorter duration of stay for depressed inpatients in bright compared to dim daylight-exposed rooms, pointing to a possible antidepressant effect of daylight conditions. Dynamic LED lighting, aiming to mimic daylight conditions, are currently been installed in several hospitals, but their feasibility is poorly investigated.

methodsTo investigate the feasibility of these systems, we developed and installed a LED-lighting system in four rooms in a psychiatric inpatient ward. The system could function statically or dynamically regarding light intensity and colour temperature. The system consisted of (A) a large LED luminaire built into the window jamb mimicking sunlight reflections, (B) two LED light luminaires in the ceiling and (C) a LED reading luminaire. In the static mode, the systems provided constant light from A and B. In the dynamic mode, the system changed light intensity and colour temperature using A, B and C. Patients with unipolar or bipolar depression were randomised to dynamic or static LED lighting for 4 weeks, in addition to standard treatment. Primary outcome was the rate of patients discontinuing the trial due to discomfort from the lighting condition. Secondary outcomes were recruitment and dropout rates, visual comfort, depressive symptoms and suicidal ideation.

resultsNo participants discontinued due to discomfort from the LED lighting. Recruitment rate was 39.8%, dropout from treatment rates were 56.3% in the dynamic group and 33.3% in the static group. 78.1% in the dynamic group were satisfied with the lighting compared with 71.8% in the static group. Discomfort from the light (glare) was reported by 11.5% in the dynamic group compared to 5.1% in the static group. Endpoint suicidal scores were 16.8 (10.4) in the dynamic and 16.3 (14.9) in the static group. The lighting system was 100% functional. The light sensor system proved unstable.

conclusionDropout from treatment was high primarily due to early discharge and with a lack of endpoint assessments. The feasibility study has influenced an upcoming large-scale dynamic lighting efficacy trial where we will use a shorter study period of 3 weeks and with more emphasis on endpoint assessments. The lighting was well tolerated in both groups, but some found intensity too low in the evening. Thus, we will use higher intensity blue-enriched light in the morning and higher intensity amber (blue-depleted) light in the evening in the upcoming study. The light sensor system needs to be improved.

trial registrationClinicalTrials.gov: NCT03363529.

Indexed as

ArchitectureBipolar disorderChronotherapyCircadianDepressionHospitalsLightLightingMajor depressive disorderRandomisationRCTSleep

Identifiers

PMID31956421
PMCPMC6961285
OpenAlexW3005355030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.