Evidence map›Paper›PMID 31956332›Full record

ArticleNutrition & metabolism2020

Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress.

Hossam Ebaid, Samir A E Bashandy, Ahmad M Abdel-Mageed, Jameel Al-Tamimi, Iftekhar Hassan, Ibrahim M Alhazza

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Hossam Ebaid1Department of Zoology, College of Science, King Saud University, Riyadh, 11451 Saudi Arabia.
Samir A E Bashandy2Department of Pharmacology, Medical Division, National Research Centre, 33 EL Bohouth St., Dokki, Cairo, 12622 Egypt.ORCID 0000-0001-5701-0320
Ahmad M Abdel-Mageed3Department of Zoology, Faculty of Sciences, Minia University, El-Minia, Egypt.
Jameel Al-Tamimi1Department of Zoology, College of Science, King Saud University, Riyadh, 11451 Saudi Arabia.
Iftekhar Hassan1Department of Zoology, College of Science, King Saud University, Riyadh, 11451 Saudi Arabia.
Ibrahim M Alhazza1Department of Zoology, College of Science, King Saud University, Riyadh, 11451 Saudi Arabia.
King Saud University · SAMinia University · EGNational Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes mellitus is a global epidemic leads to multiple serious health complications, including nephropathy. Diabetic nephropathy is a serious kidney-related complication of type 1 or 2 diabetes that is prevalent in almost 40% of the people with diabetes. We examined whether folic acid and melatonin can reduce progression of nephropathy in rats of type 1 diabetes mellitus by controlling the level of oxidative stress, glucose, lipids, and cytokines.

methodsForty-two male albino rats were distributed into six groups, (

resultsThe data indicated that diabetes significantly altered the body weight, lipids and kidney function. Diabetic rats exhibited a significant increase in plasma levels of urea, uric acid, creatinine, sodium, tumor necrosis factor alpha (TNF-α), interleukin-6(IL-6), cholesterol, triglycerides, and low-density lipoprotein (LDL). In contrast, plasma total protein, potassium, high-density lipoprotein (HDL) and interleukin-10 (IL-10) decreased significantly in diabetic rats compared to the control rats. Moreover, levels of renal malondialdehyde (MDA) and nitric oxide (NO) were significantly increased while the levels of renal glutathione(GSH), superoxide dismutase(SOD), and catalase (CAT) were significantly decreased in diabetic rats comparison to those in the control rats. Hence, diabetic rats treated with folic acid and melatonin alone as well as in combination showed improvements with respect to the indices in addition to a significant recovery observed via histopathology when compared to the diabetic group.

conclusionsThese results revealed that treatment with folic acid in combination with melatonin in diabetic rats was more effective than treatment with either of folic acid or melatonin alone to alleviate the symptoms of diabetic nephropathy.

Indexed as

Cytokine levelDiabetesFolic acidLipidogramMelatoninNephropathyOxidative status

Identifiers

PMID31956332
PMCPMC6961249
OpenAlexW3004578350

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.