Evidence map›Paper›PMID 31956324›Full record

ArticleFrontiers in immunology2019

Therapeutic Effect of Bifidobacterium Administration on Experimental Autoimmune Myasthenia Gravis in Lewis Rats.

Elena Rinaldi, Alessandra Consonni, Chiara Cordiglieri, Grazia Sacco, Camilla Crasà, Alessandra Fontana, Lorenzo Morelli, Marina Elli, Renato Mantegazza, Fulvio Baggi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Gut microbial profiles of patients with optic neuritis or myasthenia gravis.The Journal of international medical research · 2025
    Article
  5. Myasthenia gravis and nutrition.Frontiers in nutrition · 2025
    Review
  6. Histology and histopathology · 2024
    Article
  7. Article
  8. Article
  9. Gut microbes · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Gut dysbiosis in autoimmune diseases: Association with mortality.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elena RinaldiNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Alessandra ConsonniNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Chiara CordiglieriNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Grazia SaccoNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Camilla CrasàNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Alessandra FontanaDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Piacenza, Italy.
Lorenzo MorelliDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Piacenza, Italy.
Marina ElliAAT-Advanced Analytical Technologies, Fiorenzuola d'Arda, Italy.
Renato MantegazzaNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Fulvio BaggiNeurology IV - Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beneficial effects of probiotics on gut microbiota homeostasis and inflammatory immune responses suggested the investigation of their potential clinical efficacy in experimental models of autoimmune diseases. Indeed, administration of two bifidobacteria and lactobacilli probiotic strains prevented disease manifestations in the Lewis rat model of Myasthenia Gravis (EAMG). Here, we demonstrate the clinical efficacy of therapeutic administration of vital bifidobacteria (i.e., from EAMG onset). The mechanisms involved in immunomodulation were investigated with

Indexed as

BifidobacteriumAnimalsAutoimmunityCell MovementDendritic CellsDisease Models, AnimalFemaleGastrointestinal MicrobiomeHigh-Throughput Nucleotide SequencingMetagenomeMetagenomicsMyasthenia Gravis, Autoimmune, ExperimentalProbioticsRatsRats, Inbred LewRNA, Ribosomal, 16SRNA, Ribosomal, 16SEAMGimmunoregulationMGprobioticstherapeutic treatment

Identifiers

PMID31956324
PMCPMC6951413
OpenAlexW2995652507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.