ArticleCurrent biology : CB2020
Targeted Stimulation of Human Orbitofrontal Networks Disrupts Outcome-Guided Behavior.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the neurobiological effects of theta-burst stimulation (TBS) as measured using functional magnetic resonance imaging (fMRI).Brain structure & function · 2023Pooled it
- Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices.PLoS biology · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Effects of theta burst stimulation on neural connectivity and visual perception following attention modification of own-face viewing in body dysmorphic disorder.medRxiv : the preprint server for health sciences · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning.Frontiers in cellular neuroscience · 2026Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- The reward positivity is insensitive to reinforcer devaluation.Cognitive, affective & behavioral neuroscience · 2025Article
- Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.Scientific reports · 2025Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.Nature communications · 2024Article
- Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks.Nature communications · 2024Article
- What Does the Human Olfactory System Do, and How Does It Do It?Annual review of psychology · 2024Review
- Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases.Nature communications · 2024Article
- Lateral orbitofrontal cortex integrates predictive information across multiple cues to guide behavior.Current biology : CB · 2023Article
- Value dynamics affect choice preparation during decision-making.Nature neuroscience · 2023Article
- Computationally Informed Interventions for Targeting Compulsive Behaviors.Biological psychiatry · 2023Review
- Deep magnetic stimulation targeting the medial prefrontal and anterior cingulate cortices for methamphetamine use disorder: a randomised, double-blind, sham-controlled study.General psychiatry · 2023Article
- Gender difference in network relationship between inter-temporal decisions and prefrontal activation levels in internet gaming disorder.Psychoradiology · 2023Article
- Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective.Frontiers in psychiatry · 2023Article
Corrections and comments
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6 authors.
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Abstract
Outcome-guided behavior requires knowledge about the current value of expected outcomes. Such behavior can be isolated in the reinforcer devaluation task, which assesses the ability to infer the current value of specific rewards after devaluation. Animal lesion studies demonstrate that orbitofrontal cortex (OFC) is necessary for normal behavior in this task, but a causal role for human OFC in outcome-guided behavior has not been established. Here, we used sham-controlled, non-invasive, continuous theta-burst stimulation (cTBS) to temporarily disrupt human OFC network activity by stimulating a site in the lateral prefrontal cortex that is strongly connected to OFC prior to devaluation of food odor rewards. Subjects in the sham group appropriately avoided Pavlovian cues associated with devalued food odors. However, subjects in the stimulation group persistently chose those cues, even though devaluation of food odors themselves was unaffected by cTBS. This behavioral impairment was mirrored in changes in resting-state functional magnetic resonance imaging (rs-fMRI) activity such that subjects in the stimulation group exhibited reduced OFC network connectivity after cTBS, and the magnitude of this reduction was correlated with choices after devaluation. These findings demonstrate the feasibility of indirectly targeting the human OFC with non-invasive cTBS and indicate that OFC is specifically required for inferring the value of expected outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.