ArticleCell metabolism2020
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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78 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
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- The gut vagal sensory pathway drives postprandial sleep via activation of PVH-projecting GABAergic neurons in the NTS.Nature communications · 2025Article
- Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation.Nature communications · 2025Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 3 institutions in 3 countries.
Wenwen ChengDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Ian GonzalezDivision of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
Warren PanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA.
Anthony H TsangMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Jessica AdamsDivision of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA.
Ermelinda NdokaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Desiree GordianDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Basma KhouryDepartment of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
Karen RoelofsDepartment of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
Simon S EversDepartment of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
Andrew MacKinnonDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Shuangcheng WuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
Henriette Frikke-SchmidtDepartment of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
Jonathan N FlakDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
James L TrevaskisCardiovascular, Renal and Metabolic Diseases, AstraZenica LLC, Gaithersburg, MD 20878, USA.
Christopher J RhodesCardiovascular, Renal and Metabolic Diseases, AstraZenica LLC, Gaithersburg, MD 20878, USA.
So-Ichiro FukadaLaboratory of Molecular and Cellular Physiology, Osaka University, Osaka 565-0871, Japan.
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
Darleen A SandovalDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA; Department of Surgery, University of Michigan, Ann Arbor, MI 48105, USA.
David P OlsonDivision of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.
Clemence BlouetMRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: csb69@medschl.cam.ac.uk.
Martin G MyersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Division of Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: mgmyers@umich.edu.
University of Michigan–Ann Arbor · USWellcome/MRC Institute of Metabolic Science · GBOsaka University · JP
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3MCELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MProject 3: Neural mediators in the metabolic effects of Vertical Sleeve GastrectomyP01DK117821 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDOVAL, DARLEEN A. · 2019 to 2023
$9.3MMichigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2MSYTEMS AND INTEGRATIVE BIOLOGYT32GM008322 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, MALCOLM JAMES · 1990 to 2020
$5.7MUnique Roles for Defined PVH Neurons in the Control of Energy BalanceR01DK104999 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLSON, DAVID P · 2016 to 2020
$2.5MRole of GDF15 and its receptor in the CNS regulation of food intake and body weightR01DK119188 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEELEY, RANDY J · 2019 to 2022
$1.9MRole of Glucokinase in GLP-1 Regulation of Energy and Glucose HomeostasisR01DK082480 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDOVAL, DARLEEN A. · 2010 to 2014
$1.7MA Leptin-Regulated Brainstem Pathway That Controls Glucose and Energy HomeostasisR01DK098853 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 2014 to 2017
$1.4MUnique Roles for Defined PVH Neurons in the Control of Energy BalanceR56DK104999 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLSON, DAVID P · 2015 to 2015
$156kMedical Research Council MC_UU_00014/5Medical Research Council MC_UU_00014/6Medical Research Council MC_UU_12012/1Medical Research Council MC_UU_12012/5Medical Research Council MRC_MC_UU_12012/5Medical Research Council MR/M501736/1Medical Research Council MR/N003276/1NIDDK NIH HHS P01 DK117821NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK082480NIDDK NIH HHS R01 DK098853NIDDK NIH HHS R01 DK104999NIDDK NIH HHS R01 DK119188NIDDK NIH HHS R56 DK104999NIDDK NIH HHS U2C DK110768NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM008322Wellcome TrustWellcome Trust 100574/Z/12/Z
Abstract
To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating Calcr
Indexed as
EatingEnergy MetabolismAnimalsBody WeightFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptors, CalcitoninSolitary NucleusReceptors, Calcitoninanorexiaaversioncalcitonin receptorNTSobesityPBN
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.