ArticleCell2020
Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish.Nature communications · 2026Article
- Effects of aging on the mechanisms of dynamic integration between the default mode network and other brain networks: evidence based on fMRI data with natural stimulation.Brain imaging and behavior · 2026Article
- Neural sequences underlying directed turning in Caenorhabditis elegans.Nature neuroscience · 2026Article
- The cerebellum implements structured representation of valence to support adaptive behavior control.Science advances · 2026Article
- Distinct distributed neural dynamics predict pallium-dependent social approach.Nature communications · 2026Article
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Article
- Voltage imaging in zebrafish using high-speed light-sheet microscopy.Neurophotonics · 2026Review
- Short-term memory by distributed neural network oscillators in a simple nervous system.Current biology : CB · 2025Article
- Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.Biophysical journal · 2025Review
- Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors.Science robotics · 2025Article
- Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia.Research square · 2025Article
- Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2025Article
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- Sensorimotor integration enhances temperature stimulus processing.PLoS computational biology · 2025Article
- Altered locomotion and anxiety after exposure to SiOScientific reports · 2025Article
- Article
- Whole-brain neural substrates of behavioral variability in the larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.