ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2020
Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
- Technical challenges in establishing local native T1 reference ranges in cardiac MRI: a critical review.Insights into imaging · 2026Review
- Diagnostic Value of Native T1 and T2 Mapping in Differentiating Clinically Suspected Amyloidosis and Hypertrophic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2026Article
- Quantitative Cardiac MRI in COVID-19 Vaccine-Related Versus Other Types of Myocarditis: A Korean Multicenter Study.Journal of Korean medical science · 2026Article
- A semi-automated quality assurance tool for cardiovascular magnetic resonance imaging: application to outlier detection, artificial intelligence evaluation and trainee feedback.BMC medical informatics and decision making · 2025Article
- Comparison of intensity normalization methods in prostate, brain, and breast cancer multi-parametric magnetic resonance imaging.Frontiers in oncology · 2025Article
- Association of cartilageOsteoarthritis and cartilage open · 2024Article
- Novel Magnetic Resonance Imaging Tools for Hypertrophic Cardiomyopathy Risk Stratification.Life (Basel, Switzerland) · 2024Review
- Inter-scanner comparability of Z-scores for native myocardial T1 and T2 mapping.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Multi-site comparison of parametric T1 and T2 mapping: healthy travelling volunteers in the Berlin research network for cardiovascular magnetic resonance (BER-CMR).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Native T1 mapping for the diagnosis of cardiac amyloidosis in patients with left ventricular hypertrophy.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Spatial variation of covid-19 morbidity status and identification of risk zone in Tamil Nadu (India) during first wave.GeoJournal · 2023Article
- Phantom-based correction for standardization of myocardial native T1 and extracellular volume fraction in healthy subjects at 3-Tesla cardiac magnetic resonance imaging.European radiology · 2022Article
- 2021 - State of our JCMR.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Review
- Initial Experience on Hyperpolarized [1-Tomography (Ann Arbor, Mich.) · 2022Article
- A Radiomics Model for Predicting Early Recurrence in Grade II Gliomas Based on Preoperative Multiparametric Magnetic Resonance Imaging.Frontiers in oncology · 2021Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundT1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if Z-scores can be used to compare the results of MOLLI T1 mapping from different cardiovascular magnetic resonance (CMR) platforms.
methodsFirst, healthy subjects (n = 15) underwent 11 combinations of native short-axis T1 mapping (four CMR systems from two manufacturers at 1.5 T and 3 T, three MOLLI schemes). Mean and standard deviation (SD) of septal myocardial T1 were derived for each combination. T1 maps were transformed into Z-score maps based on mean and SD values using a prototype post-processing module. Second, Z-score mapping was applied to a validation sample of patients with cardiac amyloidosis at 1.5 T (n = 25) or 3 T (n = 13).
resultsIn conventional T1 analysis, results were confounded by variations in field strength, MOLLI scheme, and manufacturer-specific system characteristics. Z-score-based analysis yielded consistent results without significant differences between any two of the combinations in part 1 of the study. In the validation sample, Z-score mapping differentiated between patients with cardiac amyloidosis and healthy subjects with the same diagnostic accuracy as standard T1 analysis regardless of field strength.
conclusionsT1 analysis based on Z-score mapping provides consistent results without significant differences due to field strengths, CMR systems, or MOLLI variants, and detects cardiac amyloidosis with the same diagnostic accuracy as conventional T1 analysis. Z-score mapping provides a means to compare native T1 results acquired with MOLLI across different CMR platforms.
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